Primidone for epilepsy
Enodama
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 5 Abr 2025
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You need to take primidone regularly to prevent seizures from occurring. It is usually taken twice daily.
It may cause you to feel drowsy.
Do not drink alcohol.
Do not suddenly stop taking it as this is likely to make your fits return.
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About primidone
Tipo de medicamento | Anti-epileptic |
Usado para | Epilepsia |
También llamado | Enodama®, Liskantin®, Mysoline® |
Disponible como | Tabletas, medicina líquida oral |
If you have epilepsia, it means that you have had repeated fits (seizures). A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Different parts of the brain control different parts and functions of your body. Therefore, the symptoms that occur during a seizure depend on where the abnormal burst of electrical activity occurs. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, consciousness, or a combination of these.
Epilepsy cannot be 'cured', but the seizures can be prevented in most people by suitable anti-epileptic medication. Primidone helps prevent seizures from occurring.
Before taking primidone
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking primidone it is important that your doctor or pharmacist knows:
Si estás embarazada, intentando tener un bebé o amamantando.
Si tienes problemas para respirar.
If you have ever had problems with drug or alcohol dependence.
Si tienes problemas de hígado o riñón.
Si tienes un trastorno sanguíneo hereditario raro conocido como porfiria.
If you are taking or using any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to take primidone
Volver al contenidoBefore you start this treatment, read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about primidone and a full list of side-effects which you may experience from taking it.
Take primidone exactly as your doctor has told you. It is usually taken twice a day, although to begin with you will be prescribed a small dose to take at bedtime. This will then be increased gradually. Increasing your dose slowly allows your doctor to make sure that you have the dose that best suits you, but avoids any unwanted symptoms. Your dose will be on the label of your pack to remind you how to take the tablets. You need to take primidone regularly to prevent the fits (seizures) from occurring.
You can take the tablets before or after food. You may find it helps to swallow them with a drink of water.
If you forget to take a dose, take it as soon as you remember. If it is almost time to take your next dose, skip the missed dose and take your next dose when it is due. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIntenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
When you first start a new treatment for epilepsy there may be a change in the number or type of fits (seizures) you experience. Your doctor will advise you about this.
Different brands of primidone may act in a slightly different way in your body. Because of this your pharmacist will always try to give you tablets from the same manufacturer as you have had before. So, each time you collect a prescription, check to make sure your supply looks the same and that the brand name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to check it for you.
People with epilepsy must stop driving at first. Your doctor will advise you about when it may be possible for you to resume driving again. This will usually be after a year free of seizures.
Do not stop taking this medicine unless your doctor tells you to do so. Stopping it suddenly can cause your seizures to return and your doctor will want you to reduce your dose gradually if this is necessary. Also, taking primidone over a time may lead to your body becoming dependent on it and this is another reason why your doctor will want to reduce your dose slowly.
Emotional stress or a lack of sleep could make you more likely to have a seizure. Keeping to a regular sleep pattern and using relaxation exercises can reduce this risk. Speak with your doctor or pharmacist for advice.
If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking primidone.
If you buy any medicines, check with a pharmacist that they are suitable for you to take alongside primidone.
If you are a woman using hormonal contraception ('the pill'), discuss this with your doctor as primidone interferes with the pill, reducing its contraceptive effect. Other methods of contraception will be more suitable for you. If you want to have a family, make sure you discuss this with your doctor well in advance of becoming pregnant. This is so that you can be given advice from a specialist before you become pregnant. If you become pregnant while you are taking primidone, you should tell your doctor straightaway.
You are advised not to drink alcohol while you are on primidone. Primidone will make you feel sleepy and drinking alcohol will increase this.
While you are taking these tablets, there is a small risk that you may develop mood changes or distressing feelings, and thoughts about suicide. If this happens, you must tell your doctor straightaway.
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Can primidone cause problems?
Volver al contenidoJunto con sus efectos útiles, la mayoría de los medicamentos pueden causar efectos secundarios no deseados, aunque no todos los experimentan. Estos generalmente mejoran a medida que su cuerpo se adapta al nuevo medicamento, pero hable con su médico o farmacéutico si alguno de los siguientes efectos secundarios persiste o se vuelve problemático.
Common primidone side-effects | ¿Qué puedo hacer si experimento esto? |
Feeling unsteady or tired | Getting up or moving more slowly should help. If this continues, let your doctor know |
Feeling sleepy, eyesight problems | Make sure your reactions are normal before you use tools or machines |
Sentirse mal (náuseas) | Mantente en alimentos simples - evita comidas ricas o picantes |
Feeling short of breath, behavioural changes, mood changes (such as feeling irritable, confused, excited or depressed) | Si alguno de estos se vuelve problemático, hable con su médico |
Importante: your doctor will have discussed with you the possibility of some less common but more serious side-effects. Let your doctor know straightaway if you experience any of the following:
A high temperature (fever) and swollen glands.
Una erupción cutánea severa.
Yellowing of your skin or the whites of your eyes (jaundice).
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store primidone
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda de inmediato al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- Manufacturer's PIL, Primidone 250 mg Tablets; SERB Laboratories, The electronic Medicines Compendium. Dated February 2024.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 5 Abr 2028
5 Abr 2025 | Última versión

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