Gel de isotretinoína para el acné
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 9 Jun 2024
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Clinical author's note Michael Stewart 20/05/2021: Isotrexin® gel was discontinued in the UK in January 2020. At the time of review there are no skin preparations containing isotretinoin available in the UK. Isotretinoin skin preparations may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.
For information about taking isotretinoin as a capsule please see the medicine leaflet Cápsulas de isotretinoína para el acné.
Apply the gel once or twice a day, as directed by your doctor.
Your skin may become more sensitive to sunlight than usual. Avoid strong sunlight and do not use sunbeds.
You should avoid getting pregnant. Ask your doctor about suitable contraception.
De un vistazo
Isotretinoin gel is a rub-on medicine used for mild-to-moderate acne.
It helps unblock pores and reduces inflammation in the skin.
Do not use this gel if you are pregnant, trying for a baby, or breastfeeding.
Apply a thin layer to affected areas once or twice daily after washing your skin.
Tu piel puede volverse más sensible a la luz solar, así que usa protección solar.
It can take several weeks to see an improvement in your skin.
Common side-effects include skin irritation, redness, burning, dryness, or peeling.
About isotretinoin gel
Tipo de medicamento | A rub-on (topical) retinoid |
Usado para | Mild-to-moderate acne |
También llamado | Isotrex® (discontinued); Isotrexin® (discontinued) (contains isotretinoin and erythromycin) |
Disponible como | Gel |
Acné is the common cause of spots. Most people with acne are aged between 12 and 25, but some older and younger people are affected too. Small sebaceous glands lie just under your skin surface and make an oil (sebum) that keeps your skin supple and smooth. Tiny pores on your skin allow the sebum to come on to the surface of your skin. In acne, some of these pores become blocked, causing small pimples, blackheads and whiteheads (comedones).
Applying isotretinoin to the areas of your skin with acne will help to unblock pores and treat blackheads or whiteheads. It also has some effect on reducing inflammation. If your spots are inflamed, you may be prescribed a brand called Isotrexin® as this gel also contains an antibacterial agent called erythromycin.
Isotretinoin is also available as capsules for more severe forms of acne which have not got better by using rub-on skin treatments. There is a separate medicine leaflet which contains more information about this, called Cápsulas de isotretinoína para el acné.
Before using isotretinoin gel
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using isotretinoin gel it is important that your doctor knows:
If you are pregnant, trying for a baby or breastfeeding. You must not use isotretinoin gel if you could be pregnant.
If you have a skin problem other than acne, such as if you have eczema or rosacea.
If you or any close family members have ever had skin cancer.
If you are taking or using any other medicines. This includes any creams you are using which are available to buy without a prescription.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to use isotretinoin gel
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about isotretinoin and will provide you with a full list of the side-effects which you may experience from using the gel.
Apply isotretinoin gel exactly as your doctor tells you to. It is best if you wash and gently dry the affected areas of your skin before you apply isotretinoin. A general point is that you should apply it to all of the area where your spots occur and not just to each spot. It is usual to apply it once or twice a day at first, although your doctor may suggest you use it less than this once your skin has improved. You only need to apply a thin layer of gel. Remember to wash your hands after you have finished applying the gel.
If you have recently been using a preparation for your acne that causes your skin to peel, allow your skin to recover for a few days before you start using isotretinoin gel.
Do not use the gel on any areas of your skin which are sunburnt or sore. Also, try to avoid getting it on the sensitive areas of your skin in or around your nostrils, your eyes and your mouth. Try not to let it build up in the folds or creases of your skin.
Obteniendo el máximo de tu tratamiento
It is recommended that you use a mild soap and lukewarm water to wash with, as very hot or cold water can worsen acne. You cannot clean off blackheads. The black tip of a blackhead is actually a skin pigment and cannot be removed by cleaning or scrubbing.
Si su piel se vuelve muy seca, puede ayudar usar una crema hidratante (preferiblemente una crema sin fragancia y a base de agua). No use ungüentos ni cremas ricas en aceite, ya que podrían volver a obstruir sus poros.
You can use make-up and moisturisers, but do not apply them at the same time as you use isotretinoin gel. Try to avoid any skin products which exfoliate or dry your skin.
Isotretinoin gel can make your skin more sensitive to sunlight than usual. A sun protection cream can help if you are out in the sun on bright days, even if it is cloudy. Do not use sunbeds.
It is normal for isotretinoin treatment to take several weeks before there is a noticeable improvement in your skin. The most common reason for treatment failure is stopping treatment too soon thinking it is not working. If there is no improvement despite having used the gel for eight weeks, speak with your doctor again as there are other treatments which could be more suited to your condition.
You should avoid getting pregnant while you are using isotretinoin as there is a slight risk of harm to unborn babies. If necessary, discuss with your doctor which types of contraception are suitable for you and your partner.
Once your spots have cleared, acne commonly flares up again if you stop treatment. To prevent this, it is usual to carry on with a maintenance treatment after your spots have gone. The dose used to prevent spots from returning is often lower than that used to treat acne. It is common to need maintenance treatment for a number of years to keep acne away.
Can isotretinoin gel cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with isotretinoin gel. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common isotretinoin gel side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Skin irritation, redness, burning, dry or peeling skin | Reduce how often you are using the gel for a few days to see if this settles. If it is severe or troublesome, speak with your doctor |
If you experience any other symptoms which you think may be due to isotretinoin, speak with your doctor or pharmacist for further advice.
How to store isotretinoin gel
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Si compra algún medicamento, siempre consulte con un farmacéutico para asegurarse de que sean seguros de usar con sus otros medicamentos.
This preparation is for external use only. If you suspect that someone has swallowed some of it by accident, contact the accident and emergency department of your local hospital for advice.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás usando.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What is the difference between Isotrex® and Isotrexin®?
Isotrex® contained only isotretinoin, but has been discontinued. Isotrexin® (also discontinued) combined isotretinoin with an antibacterial agent called erythromycin, which was helpful for inflamed spots.
Can I use isotretinoin gel if I have other skin conditions like eczema or rosacea?
If you have a skin problem other than acne, such as eczema or rosacea, it's important that your doctor knows this before you start using isotretinoin gel, as it may not be suitable.
Are there any specific concerns about sun exposure when using isotretinoin gel?
Isotretinoin gel can make your skin more sensitive to sunlight. Using a sun protection cream is recommended if you are outdoors on bright days, even if it's cloudy. You should avoid using sunbeds altogether.
How long does it usually take to see an improvement in my acne after starting isotretinoin gel?
It is normal for isotretinoin treatment to take several weeks before you notice an improvement in your skin. The most common reason for treatment failure is stopping too soon, thinking it isn't working. If there's no improvement after eight weeks, you should speak with your doctor.
What should I do if my skin becomes very dry while using the gel?
If your skin becomes very dry, it may be helpful to use a moisturising cream. It's best to choose a fragrance-free and water-based cream. Avoid using ointments or oil-rich creams as they could block your pores.
Lecturas adicionales y referencias
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 22 de mayo de 2027
9 Jun 2024 | Última versión

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