Dutasterida para el agrandamiento de la glándula prostática
Avodart
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 11 May 2024
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Dutasteride is for men only. It must not be taken by women, children or adolescents.
Take one capsule each day.
Your symptoms may start to improve within a few weeks, although it can take up to six months for you to notice the full benefit.
De un vistazo
Dutasteride is a medicine for men with an enlarged prostate gland, also called benign prostatic hyperplasia (BPH).
It works by shrinking the prostate, which helps to ease problems with passing urine.
Take one capsule every day at the same time, swallowing it whole without chewing.
It can take up to six months to feel the full benefit of this medicine.
Dutasteride can harm an unborn baby, so handle with care and use contraception if your partner could become pregnant.
Tell your doctor if you develop breast pain, lumps, or nipple discharge, as these can be rare side-effects.
About dutasteride
Tipo de medicamento | 5-alpha reductase inhibitor |
Usado para | Enlargement of the prostate gland in men |
También llamado | Avodart®; |
Disponible como | Cápsulas |
La glándula prostática comúnmente se agranda en los hombres mayores. El agrandamiento de la glándula prostática también se llama hiperplasia prostática benigna (HPB). The prostate is situated close to the bladder, so its enlargement can cause problems with passing urine. Common symptoms that are experienced are having to wait before your urine starts to flow, taking longer at the toilet, dribbling urine, and a feeling that your bladder is not quite empty.
Dutasteride works by blocking the conversion of the hormone testosterone to the more potent hormone dihydrotestosterone. It does this by blocking an enzyme called 5-alpha reductase. Dihydrotestosterone is partly responsible for making the prostate enlarge. Therefore, a reduced amount of dihydrotestosterone in the prostate causes it to shrink. This helps you to pass urine more easily.
Sometimes, more than one type of medicine is needed to control the symptoms of prostate enlargement. Dutasteride is available in combination with another medicine for prostate enlargement, called tamsulosina. The combination brand is called Combodart® and it may give quicker and better relief of symptoms than either medicine alone.
Before taking dutasteride
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking dutasteride it is important that your doctor knows:
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si tienes algún problema con el funcionamiento de tu hígado.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
How to take dutasteride
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about dutasteride and will provide you with a full list of the side-effects which you may experience from taking it.
Take dutasteride exactly as your doctor tells you to. Take one capsule each day. Swallow the capsule whole - do not chew or open the capsule as this could irritate your mouth.
You can take the capsule either before or after a meal, but try to take the capsule at the same time of day each day. This will help you to remember to take your doses regularly.
If you forget to take a dose on time, take it when you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Your symptoms may start to improve within a few weeks although it can take up to six months for you to notice the full benefit. This is because it takes time for the prostate gland to gradually shrink. Because of this, it is important that you continue to take the capsules regularly, even if you don't feel a benefit straightaway.
Remember to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Consider reducing or stopping the amount of caffeine you drink (commonly found in tea, coffee and cola) and alcohol. These can make your symptoms worse, so drinking less of these things may benefit you.
If you are a smoker, stopping smoking may significantly improve your symptoms. This is because nicotine irritates the bladder. Ask your doctor for advice on quitting.
Dutasteride may cause harm to an unborn baby. Because of this, women who are pregnant should not handle these capsules if they are damaged or leaking. Also, small amounts of dutasteride will be in your semen while you are taking this medicine, and it is therefore recommended that you use a barrier method of contraception (such as a condom) if your partner could become pregnant. If you need further advice about this, speak with your pharmacist or doctor.
If you are having an operation or any medical treatment, tell the person carrying out the treatment that you are taking dutasteride. This is because dutasteride can interfere with a blood test used to detect prostate cancer, so you must tell your doctor about taking dutasteride if you need this test.
Can dutasteride cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with dutasteride. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common dutasteride side-effects (these affect fewer than 1 in 10 men) | ¿Qué puedo hacer si experimento esto? |
Reduced desire to have sex, inability to get an erection, breast tenderness | Si alguno de estos se vuelve problemático, hable con su médico |
Dizziness when taken with tamsulosin | No conduzca ni utilice herramientas o máquinas mientras esté afectado |
Importante: if you develop any pain or lumps in your breast area, or any discharge from your nipples, you should tell your doctor. This is because there have been a few rare reports of breast cancer in men taking 5-alpha reductase inhibitors like finasteride and dutasteride.
Si experimenta otros síntomas que cree que pueden deberse al medicamento, hable con su médico o farmacéutico para obtener más consejos.
How to store dutasteride
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
If you buy any medicines, always check with a pharmacist that they are safe to take alongside your prescribed medicines.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What is the difference between dutasteride and combination brands like Combodart®?
Dutasteride is a single medicine used to treat benign prostatic hyperplasia (BPH). Combodart® is a combination medicine that contains both dutasteride and tamsulosin. The article notes that combination brands like Combodart® may provide quicker and better relief of symptoms than taking either medicine alone.
Can dutasteride impact my ability to have children or my partner's pregnancy?
Yes, dutasteride can potentially harm an unborn baby. Therefore, pregnant women should not handle damaged or leaking capsules. Also, small amounts of dutasteride will be present in your semen while you are taking this medicine. If your partner could become pregnant, it is recommended to use a barrier method of contraception, such as a condom. For further advice, you should speak with your pharmacist or doctor.
Are there any lifestyle changes I can make to improve my prostate symptoms while taking dutasteride?
Yes, you can consider reducing or stopping your intake of caffeine (found in tea, coffee, and cola) and alcohol, as these can worsen your symptoms. If you smoke, stopping smoking may also significantly improve your symptoms because nicotine irritates the bladder. Your doctor can offer advice on quitting smoking.
How should I store dutasteride capsules?
You should keep all medicines, including dutasteride, out of the reach and sight of children. Store them in a cool, dry place, away from direct heat and light.
Lecturas adicionales y referencias
- Manufacturer's PIL, Avodart® 0.5 mg soft capsules; GlaxoSmithKline UK, El Compendio Electrónico de Medicamentos. Fechado en agosto de 2023.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 31 Mar 2027
11 May 2024 | Última versión

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