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Alprostadil para la disfunción eréctil

Caverject, Muse, Viridal, Vitaros

Importante: if you have a prolonged or painful erection lasting for more than four hours, contact your doctor immediately.

Your doctor will arrange to see you to check your progress regularly - it is important that you keep these appointments.

De un vistazo

  • Alprostadil is a medicine used to treat erectile dysfunction, by widening blood vessels to increase blood flow to the penis.

  • It is available as an injection, a pellet inserted into the urethra, or a cream applied to the urethra.

  • Your doctor or nurse will teach you how to use the specific type of alprostadil you are prescribed.

  • Common side-effects include pain, burning in the penis, headache, and dizziness.

  • If you experience a painful erection lasting over four hours, seek immediate medical attention.

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About alprostadil

Tipo de medicamento

Prostaglandin E1 vasodilator

Usado para

Erectile dysfunction in adult men

También llamado

Caverject®, MUSE®, Viridal® Duo, Vitaros®

Disponible como

Injection, urethral application, urethral cream

Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis. Alprostadil is a vasodilator, which means that it works by widening (dilating) blood vessels to improve the flow of blood. When administered to the penis, blood flow to this area is increased, resulting in an erection usually within 10-15 minutes.

Alprostadil is available as an injection treatment, which is where you inject alprostadil into the base of your penis. It is available as a urethral application, which is where you place a small pellet containing alprostadil into your urethra (the tube which your urine passes through and which opens at the end of your penis). It is also available as a cream which is applied to the opening of the urethra on the tip of the penis. You will be taught how to use the preparation you have been prescribed.

Alprostadil is available on prescription but it is only prescribed on the NHS under certain circumstances.

Before using alprostadil

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start using alprostadil it is important that your doctor knows:

  • If you have any disease, injury, or any abnormality of your penis, or if you have been told you have a problem in your urethra.

  • If you have been advised for medical reasons not to have sex.

  • If you have any problems with feeling dizzy or faint.

  • If you have any heart or blood vessel problems.

  • Si tienes presión arterial alta (hipertensión).

  • Si tienes niveles altos de azúcar en la sangre (diabetes mellitus).

  • Si eres fumador.

  • If you have sickle cell disease.

  • If you have had bone marrow cancer or leukaemia.

  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. It is particularly important that you tell your doctor if you are using any other product to help treat erectile dysfunction.

  • Si alguna vez has tenido una reacción alérgica a un medicamento.

How to use alprostadil

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the specific brand of alprostadil you have been given, diagrams to remind you how to use it, and a full list of the side-effects which may occur.

If prescribed alprostadil injection (Caverject® or Viridal® Duo)

  • The injection is administered at the base of your penis. When starting the treatment, your doctor will give you a small dose and then gradually increase the dose if necessary. This is to make sure that you have the dose that helps your condition and avoids any unwanted symptoms. Your first injection will be given to you by a doctor or nurse, although after proper training and instruction you will be able to do it yourself at home. It is important that you ask if you are unsure about any of the instructions you are given.

  • Each time you inject alprostadil, try to use a slightly different site as this will help to prevent any skin problems.

  • After using alprostadil injection, you must leave at least 24 hours before using another. You must not use alprostadil injection more than three times a week.

  • Never use, or try to straighten, an injection which has a bent or broken needle. If you discover a bent needle, discard the injection and select a new one.

If prescribed alprostadil urethral application (MUSE®)

  • It is recommended that you pass urine just before inserting a pellet, as this moistens your urethra and makes the insertion more comfortable.

  • Your first dose may be given to you by a doctor or nurse. This is to show you how to use the applicator, and also to make sure you have the dose that helps your condition and avoids any unwanted symptoms. Your doctor or nurse will train you to use the applicator before suggesting you do it yourself at home. It is important that you ask if you are unsure about any of the instructions you are given.

  • If your partner is pregnant, it is important that you use a barrier method of contraception (such as a condom) during sex. This is to help guard against any harm to the unborn baby. It will also help avoid any irritation of the vagina of your partner.

  • You must not use more than two doses in any 24-hour period, and you must not use more than seven doses a week.

If prescribed alprostadil urethral cream (Vitaros®)

  • Vitaros® cream is available in one strength - 300 micrograms. The cream is supplied in a container which looks like a syringe (although it must not be inserted into your penis or injected in any way). Each container is to be used once only.

  • Your first dose may be given to you by a doctor or nurse. This is to show you how to use the cream correctly before you do it yourself at home. It is important that you ask if you are unsure about any of the instructions you are given.

  • It is usual for the cream to start to work within 5-30 minutes and for its effects to last an hour or two, although this can vary from person to person.

  • If your partner is pregnant, it is important that you use a barrier method of contraception (such as a condom) during sex. This is to help guard against any harm to the unborn baby. It will also help avoid any irritation of the vagina of your partner.

  • You must not use more than one dose in any 24-hour period, and you must not use more than three doses a week.

Obteniendo el máximo de tu tratamiento

  • Intenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.

  • Discuss with your doctor whether you can make any lifestyle changes that may help your condition. For example, reducing stress in your life, stopping smoking if you are a smoker, or cutting back on drinking lots of alcohol.

  • Injections of alprostadil may cause a small amount of bleeding at the site of the injections. This could increase the risk of sexually transmitted diseases. If you are concerned about this, ask your doctor for advice about 'safe sex'.

  • Make sure you follow the instructions you have been given for disposing of used injections or applicators.

  • Si compras algún medicamento, siempre consulta con un farmacéutico que sean adecuados para tomar con tus otros medicamentos.

Can alprostadil cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with alprostadil. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve after an hour or so, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common alprostadil side-effects (these affect more than 1 in 10 men)

¿Qué puedo hacer si experimento esto?

Painful penis, or a burning sensation

This should soon pass, but if troublesome, speak with your doctor for advice

Common alprostadil side-effects (these affect fewer than 1 in 10 men)

¿Qué puedo hacer si experimento esto?

Prolonged and painful erection

If this lasts for more than four hours, you

must

contact a doctor straightaway. If it lasts for more than one hour but less than four hours, make an appointment with your doctor to discuss reducing your dose

Headache, feeling dizzy or light-headed

Getting up more slowly may help, but these feelings should soon pass. Do not drive and do not use tools or machines while dizzy

Bleeding from the site of application (injection only), bruising

This should not last long

Testicular pain, leg cramps

If troublesome, speak with your doctor for advice

Si experimenta otros síntomas que cree que pueden deberse al medicamento, hable con su médico o farmacéutico para obtener más consejos.

How to store alprostadil

  • Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

  • If you have been prescribed MUSE® or Vitaros®, your supply should be stored in a refrigerator. Pouches of MUSE® can be kept out of the fridge for up to 14 days before use, if required. Sachets of Vitaros® can be kept out of the fridge for up to three days before use. If they remain unused after these times, they should be disposed of.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

Nunca use más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tenido una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.

Si vas a someterte a una operación o a un tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.

This medicine is for you. Never give it to other people, even if their condition appears to be the same as yours.

Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.

Informar efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

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Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.

Preguntas frecuentes

When can alprostadil be prescribed on the NHS?

Alprostadil is available on prescription, but it is only prescribed on the NHS under specific circumstances. The article does not detail these circumstances, so you'll need to discuss this with your doctor.

What is the maximum frequency for using alprostadil injections?

You must not use alprostadil injection more than three times a week. Additionally, you need to leave at least 24 hours between using doses.

How often can I use alprostadil urethral applications (MUSE®)?

You must not use more than two doses of MUSE® in any 24-hour period. In total, you must not use more than seven doses per week.

How often can I use alprostadil urethral cream (Vitaros®)?

You must not use more than one dose of Vitaros® cream in any 24-hour period. The maximum number of doses you can use per week is three.

What should I do if my erection is prolonged or painful after using alprostadil?

If you experience a prolonged and painful erection that lasts for more than four hours, you must contact a doctor straight away. If it lasts for more than one hour but less than four hours, you should make an appointment with your doctor to discuss reducing your dose.

How long can MUSE® and Vitaros® be kept out of the refrigerator?

Pouches of MUSE® can be kept out of the fridge for up to 14 days before use. Sachets of Vitaros® can be kept out of the fridge for up to three days before use. If they remain unused after these times, they should be disposed of.

What should I do if I suspect an overdose of alprostadil?

If you suspect that you or someone else might have had an overdose of alprostadil, you should go to the accident and emergency department of your local hospital. Remember to take the medicine container with you, even if it is empty.

Lecturas adicionales y referencias

Sobre el autorVer biografía completa

Imagen del autor

Michael Stewart, MRPharmS

Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico

BPharm (Hons), MRPharmS

Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.

Acerca del revisor

Imagen del autor

Sid Dajani

Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.

Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • Próxima revisión: 18 de septiembre de 2026
  • 19 Sept 2023 | Última versión

    Última actualización por

    Michael Stewart, MRPharmS

    Revisado por pares por

    Sid Dajani
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