Can I take Vitamin C and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known negative interaction between Vitamin C (ascorbic acid) and Vitamin D (cholecalciferol). In fact, they are often taken together in multivitamin supplements.
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Why this happens
These vitamins use different pathways for absorption and metabolism. Vitamin C is water-soluble and Vitamin D is fat-soluble, meaning they do not compete for the same transport systems in the body.
What you should do
Back to contentsIt is safe to take these two vitamins together. For the best absorption of Vitamin D, it is recommended to take it with a meal that contains some fat (such as yoghurt, eggs, or avocado).
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Important precautions
Back to contentsKidney stones (renal calculi)
High doses of vitamin C can increase the amount of oxalate in your urine, which significantly raises the risk of developing kidney stones, especially if you have had them before.
Hypercalcaemia (high blood calcium)
You must not take Vitamin D if you have high levels of calcium in your blood or urine, as it can cause calcium to build up in your body and damage your kidneys or heart.
G6PD deficiency
Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency.
Food and drink warnings
Back to contentsHigh-fat meals
Vitamin D is fat-soluble. It is best absorbed when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy). Taking it on an empty stomach may reduce its effectiveness.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Atorvastatin and Spironolactone together?
Taking these two medicines together can occasionally lead to a build-up of potassium in your blood (hyperkalaemia). While both drugs are often prescribed together safely, they can both influence how your body handles minerals and muscle health. There is also a very small increased risk of muscle-related side effects.
Treatment and medication
Can I take Atorvastatin and Rivaroxaban together?
Taking atorvastatin and rivaroxaban together may slightly increase the levels of rivaroxaban in your blood. This could potentially increase the risk of bleeding, such as bruising more easily, nosebleeds, or bleeding from the gums.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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