Can I take Paracetamol and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
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Shortec is a brand name for oxycodone. Many versions of oxycodone are sold as 'combination' products that already contain paracetamol (such as Percocet). If you take Shortec alongside paracetamol, the main risk is accidentally taking too much paracetamol. Taking more than the recommended dose of paracetamol can cause serious, life-threatening liver damage. Additionally, both drugs can cause drowsiness, though this effect is mainly driven by the Shortec.
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Why this happens
There is no direct 'clash' between how these two drugs work; in fact, they are often prescribed together because they kill pain in different ways. However, because paracetamol is hidden in many different cold, flu, and pain medicines, it is very easy to exceed the safe daily limit (4 grams or eight 500mg tablets in 24 hours) when using multiple products.
What you should do
It is generally safe to take these together as long as you check your labels carefully. Ensure your Shortec capsules do not already contain paracetamol. Do not exceed 4000mg (4 grams) of paracetamol in any 24-hour period. If you feel excessively sleepy, dizzy, or have trouble breathing, seek medical help immediately. Always tell your pharmacist if you are buying over-the-counter paracetamol while being prescribed Shortec.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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