Can I take Naproxen bp and Shortec together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking naproxen and Shortec (oxycodone) together can increase the risk of side effects such as drowsiness, dizziness, and confusion. There is also a higher risk of stomach irritation or ulcers if these are used long-term, though they work in different ways to relieve pain.
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Why this happens
Naproxen is an anti-inflammatory (NSAID) and Shortec is an opioid. While they do not directly interfere with how the body breaks each other down, their sedative effects can add together (additive effect). Additionally, both can occasionally cause stomach upset.
What you should do
It is generally safe to take these together if prescribed by your doctor, as they are often used together for stronger pain relief. However, you should be careful when driving or using machinery until you know how the combination affects you. Avoid alcohol, as it will make the drowsiness much worse. If you develop severe stomach pain or black, tarry stools, stop taking them and contact a doctor immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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