Can I take Moringa leagg and Progynova together?
Drug interaction guide
Originally published 25 Jan 2026
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Moringa may reduce the effectiveness of Progynova (estradiol). This could lead to your hormone replacement therapy or contraception not working as well as it should. Additionally, both substances are processed by the liver, which could theoretically affect how much of the medication stays in your bloodstream.
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Why this happens
Moringa oleifera is thought to have 'antioestrogenic' properties, meaning it may block or interfere with the way oestrogen works in the body. It may also speed up the liver enzymes (specifically CYP3A4) that break down Progynova, causing the medicine to leave your body too quickly.
What you should do
You should consult your doctor before taking Moringa alongside Progynova. If you decide to use both, monitor for signs that your medication isn't working, such as a return of menopause symptoms or breakthrough bleeding.
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Important precautions
Blood clots and stroke
This medicine significantly increases your risk of developing blood clots in the legs (DVT) or lungs (PE). Seek immediate medical help if you experience painful leg swelling, sudden chest pain, or breathlessness.
Breast and endometrial cancer
Long-term use can increase the risk of breast cancer and thickening of the womb lining. You must report any unexplained vaginal bleeding to your doctor immediately.
Food and drink warnings
Grapefruit juice
Grapefruit juice can increase the levels of estradiol in your blood, which may increase the risk of side effects such as breast tenderness, nausea, or headaches. It is best to avoid large amounts of grapefruit juice while taking this medicine.
Alcohol
Drinking alcohol while taking oestrogen replacement therapy can lead to higher levels of estradiol in your blood than intended. This may increase the risk of side effects. It is advisable to keep your alcohol intake within recommended limits.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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