Can I take Dapagliflozin and Ramipril together?
Drug interaction guide
Originally published 14 Mar 2026
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Taking these two medicines together can increase the risk of your blood pressure dropping too low (hypotension) and may affect how well your kidneys work. It can also lead to high levels of potassium in your blood.
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Why this happens
Both medicines work in ways that lower blood pressure and affect the kidneys. Ramipril (an ACE inhibitor) relaxes blood vessels, while dapagliflozin (an SGLT2 inhibitor) acts as a mild diuretic, causing you to lose fluid through your urine. Together, they can cause dehydration or put extra strain on the kidneys.
What you should do
Back to contentsYou can take these together, but your doctor should monitor your kidney function and blood pressure regularly, especially when starting or changing doses. Make sure to stay well-hydrated. Seek medical advice if you feel very dizzy, lightheaded, or notice a significant change in how much you urinate.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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