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Can I take Codeine and Morphine together?

Guía de interacción de medicamentos

Taking codeine and morphine together significantly increases the risk of serious side effects, including extreme sleepiness, dizziness, and dangerous breathing problems. Because both drugs are strong painkillers from the same family (opioids), they 'stack' on top of each other, which can lead to an accidental overdose.

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Por qué sucede esto

Both codeine and morphine work by attaching to the same receptors in the brain and spinal cord to block pain. Additionally, the body naturally converts a portion of codeine into morphine after you swallow it. Taking both means you are essentially taking a double dose of morphine, which can overwhelm the central nervous system.

You should not take codeine and morphine together unless specifically instructed and closely monitored by a specialist. If you have been prescribed both, speak to your doctor or pharmacist immediately to clarify the dosing schedule. Seek emergency medical help if you experience extreme drowsiness, confusion, shallow breathing, or difficulty waking up.

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Breathing problems (e.g. COPD, severe asthma)

These medicines can dangerously slow your breathing. Do not take them if you have severe lung disease or are having an asthma attack.

Consumo de alcohol

Drinking alcohol while taking these medicines significantly increases the risk of life-threatening breathing difficulties and extreme sleepiness.

Adicción y Dependencia

Codeine contains an opioid which can cause addiction if used for more than 3 days. Long-term use can lead to withdrawal symptoms when you stop.

Lactancia

No tome codeína mientras esté amamantando. Esta pasa a la leche materna y puede causar problemas respiratorios potencialmente mortales o somnolencia extrema en su bebé.

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Combining alcohol with strong painkillers like codeine or morphine significantly increases the risk of dangerous side effects, such as extreme sleepiness, breathing difficulties, and a potentially fatal overdose.

Jugo de toronja

Grapefruit juice can interfere with how your body processes codeine. This may make the medicine less effective at relieving pain or, in some cases, increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice while taking codeine.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 24 Ene 2026 | Publicado originalmente
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