Can I take 12.5mg and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking Rybelsus (semaglutide) alongside atenolol may increase the risk of your blood sugar levels dropping too low (hypoglycaemia). Additionally, atenolol can 'mask' or hide the common warning signs of low blood sugar, such as a fast heartbeat or palpitations.
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Why this happens
Rybelsus lowers blood sugar. While atenolol is for blood pressure, it can also lower blood sugar or make it harder for your body to recover from a 'sugar crash'. Crucially, atenolol blocks the 'fight or flight' response (adrenaline) that usually causes your heart to race when your sugar is low, meaning you might not realise you are in danger until the symptoms are severe.
What you should do
You can take these together, but you must be extra vigilant. Monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise other signs of low blood sugar that atenolol doesn't hide, such as sweating, dizziness, hunger, or confusion. If you feel unwell, treat the low sugar immediately and inform your GP.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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