Can I take 12.5mg and Empagliflozin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can significantly increase the risk of your blood sugar dropping too low (hypoglycaemia). It can also increase the risk of dehydration and low blood pressure.
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Why this happens
Both medicines work to lower blood sugar but in different ways. Glibenclamide (the 12.5mg dose mentioned) stimulates the pancreas to release more insulin, while empagliflozin helps the kidneys remove sugar through urine. When used together, their effects add up, which can lower blood sugar more than intended. Additionally, both can have a mild diuretic effect, increasing the risk of fluid loss.
What you should do
You must speak to your doctor before taking these together. Your doctor may need to reduce your dose of glibenclamide to prevent your blood sugar from dropping too low. Ensure you know how to recognise and treat a 'hypo' (shaking, sweating, hunger, irritability) and drink plenty of water to stay hydrated.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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