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Ambrisentan para la hipertensión pulmonar

Volibris

Ambrisentan is used to treat high blood pressure in people who have pulmonary arterial hypertension.

The usual dose is one 5 mg tablet daily. You can take ambrisentan either with or without food.

The most common side-effects are headache, and swollen feet and ankles.

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About ambrisentan

Tipo de medicamento

A vasodilator antihypertensive medicine, called an endothelin receptor antagonist

Utilizado para

Pulmonary arterial hypertension in adults

También llamado

Volibris®

Disponible como

Tabletas

Ambrisentan is prescribed to treat pulmonary arterial hypertension (PAH). This is a condition where there is too high a blood pressure in the blood vessels that supply the lungs from the heart.

Ambrisentan relaxes the muscle cells in the walls of the blood vessels to your lungs, allowing them to become wider (dilated). This reduces the pressure in these blood vessels and allows blood to flow more easily through them. In turn, this increases the supply of blood to your lungs and improves your ability to do physical activities. It will be prescribed for you by a doctor who is a specialist.

Before taking ambrisentan

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking ambrisentan it is important that your doctor knows:

  • If you are or could become pregnant, or if you are breastfeeding.

  • Si tiene algún problema con el funcionamiento de su hígado, o si tiene algún problema con el funcionamiento de sus riñones.

  • If you have been told you have a reduced number of red blood cells (anaemia).

  • If you have been told you have a condition called idiopathic pulmonary fibrosis (IPF), where there is scarring in your lungs.

  • Si alguna vez ha tenido una reacción alérgica a un medicamento.

  • Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.

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How to take ambrisentan tablets

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about ambrisentan, and it will also provide you with a full list of the side-effects which you could experience from taking it.

  • Take ambrisentan exactly as your doctor tells you to. The usual dose is one 5 mg tablet daily, although your doctor may increase the strength of your tablets to 10 mg if a higher dose is needed. Unless your doctor tells you otherwise, you can generally take your dose at a time of day that suits you. You should, however, try to take each of your doses at a similar time of day, each day.

  • Swallow the tablets whole with a drink of water - do not break or chew the tablets. You can take ambrisentan tablets either with or without food.

  • Si olvida tomar una dosis, tómela en cuanto se acuerde. Si no se acuerda hasta el día siguiente, omita la dosis olvidada del día anterior y tome la dosis que le corresponde normalmente. No tome dos dosis al mismo tiempo para compensar la dosis olvidada.

Aproveche al máximo su tratamiento

  • Try to keep all your regular appointments with your doctor. This is so your doctor can check on your progress. You will need to have regular blood tests while on ambrisentan to check that you do not develop anaemia. Your doctor will also want to check that your liver stays healthy. Signs that your liver may not be working properly are feeling sick, a high temperature, dark urine, jaundice, stomach pain, feeling unusually tired, and flu-like symptoms - let your doctor know straightaway if you develop any of these.

  • You must avoid getting pregnant while you are taking ambrisentan because it could cause harm to an unborn baby. Make sure you have discussed with your doctor which types of contraception are suitable for you and your partner.

  • It is possible that ambrisentan taken long-term reduces fertility in men by lowering the sperm count. Discuss this with your doctor if you have any concerns about it.

  • If you are due to have an operation or some other medical treatment, it is important that you tell the person carrying out the treatment that you are taking ambrisentan.

  • If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable for you to take with ambrisentan.

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Can ambrisentan tablets cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with ambrisentan. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.

Muy común

ambrisentan side-effects (these affect more than 1 in 10 people)


¿Qué puedo hacer si me ocurre esto?

Dolor de cabeza

Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza persisten, consulte a su médico.

Pies o tobillos hinchados

Si esto le resulta molesto, hable con su médico.

Común

ambrisentan side-effects (these affect fewer than 1 in 10 people)

¿Qué puedo hacer si me ocurre esto?

Sensación de mareo, cansancio o debilidad

No conduzca ni utilice herramientas o máquinas mientras esté afectado

Flushing, sinus infections, nosebleeds, feeling short of breath, a stuffy or runny nose, the sensation of having a 'thumping heart' (palpitations), chest pain

Si alguno de ellos le resulta molesto, hable con su médico

Feeling sick (nausea) or being sick (vomiting), stomach ache, diarrhoea

Eat simple meals - avoid fatty or spicy food. Drink plenty of water to replace lost fluids

Estreñimiento

Eat a healthy balanced diet and drink plenty of water

Cambios en algunos análisis de sangre

Su médico comprobará regularmente

Si experimenta cualquier otro síntoma que crea que puede deberse a los comprimidos, hable con su médico o farmacéutico para que le aconsejen.

How to store ambrisentan

  • Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.

Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.

No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.

Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.

Informar de los efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.

Lecturas complementarias y referencias

Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • Fecha de la próxima revisión: 8 de enero de 2026
  • 9 Ene 2023 | Última versión

    Última actualización

    Michael Stewart, MRPharmS

    Revisado por expertos

    Sid Dajani
  • 5 Oct 2013 | Originally published

    Autores:

    Helen Allen, Farmacéutica
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