Can I take Sertraline and Tramadol together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together significantly increases the risk of a rare but very serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In severe cases, it can lead to seizures or loss of consciousness.
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Why this happens
Both sertraline (an SSRI antidepressant) and tramadol (a strong painkiller) increase the levels of serotonin in the brain. When used together, the effect is additive, which can push serotonin levels into a dangerous range. Additionally, sertraline can slow down the way the body breaks down tramadol, leading to higher levels of the painkiller in your system.
What you should do
You should speak to your doctor before taking these two medicines together. They may prefer to prescribe an alternative painkiller that does not affect serotonin. If your doctor decides you must take both, they will monitor you closely. Seek urgent medical help immediately if you experience high fever, shivering, severe muscle stiffness, or confusion.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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