Can I take Lercanidipine and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
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Both lercanidipine and pregabalin can cause dizziness, sleepiness, and swelling in the ankles or legs (oedema). Taking them together may increase the likelihood or severity of these side effects. You may feel more lightheaded, especially when standing up quickly, or notice more pronounced swelling in your lower limbs.
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Why this happens
Lercanidipine works by relaxing blood vessels, which can sometimes cause fluid to leak into the tissues (swelling). Pregabalin affects the central nervous system and can also cause fluid retention and drowsiness. When used together, their similar side-effect profiles can have an additive effect on your body.
What you should do
It is generally safe to take these together, but you should be aware of increased side effects. To stay safe, get up slowly from a sitting or lying position to avoid dizziness. If you notice significant swelling in your ankles, or if the drowsiness interferes with your daily activities (like driving), speak to your GP. Do not stop taking either medication without medical advice.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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