Sertraline
Contulen, Lustral, Zoloft
Revisado por pares por Dr Colin Tidy, MRCGPÚltima actualización por Michael Stewart, MRPharmSLast updated 30 de agosto de 2023
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
Try to take sertraline at the same time each day.
It may take up to four weeks after starting this treatment before you feel the full benefit. Do not stop taking it, even if you feel like it is not helping.
Common side effects of sertraline include feeling sick (nausea), headache, trouble sleeping, diarrhoea, and feeling dizzy, tired or weak.
Tell your doctor if you feel that you are not getting any better, or if you experience any troublesome side effects.
En este artículo:
Video picks for Medicamentos para el sistema nervioso
Continúa leyendo abajo
About sertraline
Tipo de medicamento | A selective serotonin reuptake inhibitor (SSRI) antidepressant |
Usado para | Depression, and anxiety disorders (such as panic disorder, social anxiety disorder, post-traumatic stress disorder), and obsessive-compulsive disorder (OCD) |
También llamado (Reino Unido) | Contulen®; Lustral® |
También llamado (EE.UU.) | Zoloft® |
Disponible como | Tablets, oral liquid medicine (USA) |
Dosage | 50 mg, 100mg |
What is sertraline used for?
Volver al contenidoSertraline is a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI). It is used to treat depresión, anxiety disorders, and trastorno obsesivo-compulsivo.
SSRIs like sertraline increase the amount of circulating serotonin available in your brain. This can help improve symptoms of depression, anxiety disorders, and OCD.
An anxiety disorder is a condition where anxiety is a major symptom. Trastorno de pánico, social anxiety disorder, y trastorno de estrés postraumático are all anxiety disorders. OCD is a condition where you have recurring and persistent ideas that make you do repetitive actions.
Continúa leyendo abajo
Side effects of sertraline
Volver al contenidoThe most common side effects of sertraline are:
Feeling sleepy, dizzy or weak.
Feeling sick or being sick (vomiting).
Dolor de cabeza.
Mood changes such as feeling anxious, nervous or agitated.
Sintiéndose inquieto o tembloroso.
Flushing and sweating.
Boca seca.
Difficulty sleeping and bad dreams.
Dolor de garganta.
Tingling feelings.
Lack of concentration.
Problemas de visión.
Yawning.
Swallowing problems.
Reduced sexual drive (libido).
Changes in appetite.
General aches and pains.
Encontrará una lista completa en el prospecto del fabricante que se suministra con su medicamento. Los efectos no deseados a menudo mejoran a medida que su cuerpo se adapta al nuevo medicamento, pero hable con su médico o farmacéutico si alguno de los siguientes persiste o se vuelve problemático.
How to manage sertraline side effects
Volver al contenidoCommon sertraline side effects | ¿Qué puedo hacer si experimento esto? |
Feeling sleepy, dizzy or weak | Si esto sucede, no conduzcas y no uses herramientas ni máquinas |
Feeling sick or being sick, constipation or diarrhoea, indigestion | Mantente con alimentos simples |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Mood changes such as feeling anxious, nervous or agitated. Feeling restless or shaky | This may happen when you first start taking sertraline but it usually settles within a few days. If it becomes troublesome or severe, speak with your doctor |
Dry mouth, difficulty sleeping, bad dreams, sore throat, tingling feelings, lack of concentration, eyesight problems, ringing noises, flushing, sweating, yawning, reduced sexual drive or ability, change in appetite, aches or pains, swallowing problems | Hable con su médico si alguno de estos se vuelve problemático |
Importante: a few people taking sertraline have developed an allergic-type reaction. You should contact your doctor straightaway if you develop any swelling around your face, any difficulties breathing, or a severe rash.
On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:
Músculos rígidos o movimientos 'bruscos'.
Latidos del corazón inusualmente rápidos.
High temperature (fever), feeling sick (nausea) or being sick (vomiting), diarrhoea.
Sentirse delirante o ver visiones (alucinar).
If you experience any other symptoms that you think may be due to this medicine, speak with your doctor or pharmacist for further advice.
Continúa leyendo abajo
Who should not take sertraline?
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sertraline it is important that your doctor knows:
Si estás embarazada, intentando tener un bebé o amamantando.
If you have a heart condition, or a liver or kidney disorder.
Si tienes epilepsia.
Si tienes niveles altos de azúcar en la sangre (diabetes mellitus).
If you have an eye problem called glaucoma.
If you have ever had a bleeding disorder.
If you have ever had abnormally 'high' moods, called mania.
If you are being treated with electroconvulsive therapy (ECT).
Si alguna vez has tenido una reacción alérgica a un medicamento.
If you have taken an antidepressant known as a monoamine-oxidase inhibitor (MAOI) within the previous two weeks.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
How to take sertraline
Volver al contenidoRead the manufacturer's printed information leaflet from inside the pack. It will give you more information about sertraline and will provide you with a full list of the side effects which you may experience from taking it.
Take sertraline exactly as your doctor tells you to - it is taken once daily. Most doctors recommend that it is taken either in the morning o in the evening. Try to take your doses at the same time of day each day.
There are two strengths of tablet available - 50 mg and 100 mg. Your doctor will tell you which strength is right for you.
If you are being treated for an anxiety disorder, your doctor may prescribe a low dose for you to begin with, and then gradually increase it. This is because slowly increasing the dose helps to reduce the risk of side effects.
You can take sertraline before or after food.
Si olvida tomar una dosis, tómela tan pronto como lo recuerde. Si no lo recuerda hasta el día siguiente, omita la dosis olvidada. No tome dos dosis juntas para compensar una dosis olvidada.
Getting the most from sertraline
Volver al contenidoIntenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
If you buy any medicines, check with a pharmacist that they are safe to take with sertraline. This is because several medicines which are available from general retail outlets can interfere with this treatment.
In particular, do not take the herbal remedy St John's wort, and ask for advice before buying any anti-inflammatory painkillers.
While you are taking sertraline, you may have thoughts about harming yourself or ending your life. These thoughts may also be associated with your condition. It is very important that you tell your doctor about this if it happens.
Do not stop taking sertraline unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
You should expect that a course of treatment will last for several months. This is normal and helps to prevent your symptoms from recurring.
If you have diabetes, you may need to check your blood glucose more frequently, as sertraline may affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
A few people taking sertraline find that their skin is more sensitive to sunlight than normal. Until you know how your skin reacts, use a sun cream with a high sun protection factor (SPF) in strong sunlight.
There are several types of antidepressants and they differ in their possible side effects. If you find that sertraline does not suit you then let your doctor know, as another may be found that will.
How to store sertraline
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
Si vas a someterte a una operación o a un tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.
Preguntas frecuentes
Volver al contenidoHow long does sertraline take to work?
Sertraline can take a week or two before the effect begins to build up, and 4-6 weeks before you feel the full benefit of it working. Do not stop taking it even if you feel like it is not helping.
Can I drink alcohol when taking sertraline?
Your doctor is likely to recommend that you do not drink alcohol while you are on sertraline, as it increases the risk of side effects, such as feeling sleepy. If you drink alcohol you should ask your doctor for advice.
Can I have grapefruit whilst taking sertraline?
Do not drink grapefruit juice while you are on sertraline. This is because a chemical in grapefruit juice increases the amount of sertraline in your bloodstream. This makes side effects more likely.
When do sertraline side effects start?
Side effects from sertraline often start within the first few days of taking the medicine. Some people may notice them straight away, while others find they appear after a week or so. These effects are usually mild and tend to improve as your body adjusts.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- Manufacturer's PIL, Lustral® 50 mg and 100 mg tablets; Upjohn UK Limited, The electronic Medicines Compendium. Dated April 2023.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Continúa leyendo abajo
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Siguiente revisión prevista: 29 de agosto de 2026
30 de agosto de 2023 | Última versión

Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
By subscribing you accept our Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.