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¿Puedo tomar antihistamínicos con alcohol?

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Combining alcohol with antihistamines can make you feel extremely drowsy, dizzy, and unsteady on your feet. It can also slow down your breathing and significantly impair your coordination and judgement. This effect is much stronger with older 'sedating' antihistamines (like chlorphenamine or promethazine), but it can also happen with newer 'non-drowsy' versions (like cetirizine or loratadine).

Por qué sucede esto

Both alcohol and antihistamines act as 'depressants' on the central nervous system. This means they both slow down brain activity. When taken together, they have an 'additive effect', meaning they reinforce each other's side effects, making the sedation much more powerful than if you took either one alone.

Lo que deberías hacer

It is best to avoid or strictly limit alcohol when taking any antihistamine. Do not drive, operate machinery, or perform tasks that require you to be alert if you have consumed alcohol while taking this medication. If you are taking an older, sedating antihistamine (often found in night-time cold and flu remedies), you should avoid alcohol entirely.

Precauciones importantes

Depresión del Sistema Nervioso Central

Combining alcohol with antihistamines (especially older types like chlorphenamine or promethazine) significantly increases drowsiness, impairs coordination, and can dangerously slow your breathing. Do not drive or operate machinery if using both.

More about Alcohol

More about Antihistamines

Glaucoma and Urinary Retention

Sedating antihistamines can worsen narrow-angle glaucoma and cause severe difficulty passing urine, particularly in men with an enlarged prostate.

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Fruit Juices (Grapefruit, Orange, Apple)

Do not drink grapefruit, orange, or apple juice while taking fexofenadine. These juices can significantly reduce the amount of medicine your body absorbs, making the treatment less effective. It is best to take fexofenadine with water.

More about Fexofenadine (Allegra)

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.
  • 30 Abr 2026 | Publicado originalmente

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