Can I take Danazol and Tramadol together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking danazol and tramadol together can increase the amount of tramadol in your bloodstream. This makes you much more likely to experience serious side effects, such as extreme sleepiness, breathing difficulties, and a rare but dangerous condition called serotonin syndrome (which causes confusion, sweating, and shaking). It may also increase the risk of having a seizure.
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Why this happens
Tramadol is broken down in the liver by specific enzymes. Danazol blocks these enzymes, preventing the body from clearing the tramadol. This leads to a build-up of the painkiller to potentially toxic levels.
What you should do
You should speak to your doctor before taking these two medicines together. Your doctor may need to adjust your dose of tramadol or monitor you more closely for side effects. If you feel unusually dizzy, sleepy, or have trouble breathing, seek medical help immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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