norrin cystine knot growth factor NDP
Última actualización 26 Sept 2025
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
The NDP gene provides instructions for making a protein called norrin. Norrin participates in chemical signaling pathways that affect the way cells and tissues develop. Studies suggest that norrin may play a role in Wnt signaling, which is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.
Normal function
The NDP gene provides instructions for making a protein called norrin. Norrin participates in chemical signaling pathways that affect the way cells and tissues develop. Studies suggest that norrin may play a role in Wnt signaling, which is important for cell division (proliferation), attachment of cells to one another (adhesion), cell movement (migration), and many other cellular activities.
Norrin is one of many proteins, or ligands, that can attach (bind) to other proteins called frizzled receptors. These receptors are embedded in the outer membranes of cells. Norrin binds with the receptor frizzled-4 (produced from the FZD4 gene). The two proteins fit together like a key in a lock. When a ligand binds to a frizzled receptor, it initiates a multi-step process that regulates the activity of certain genes.
The norrin protein and frizzled-4 participate in developmental processes that are believed to be crucial for normal development of the eye and other body systems. In particular, norrin seems to play critical roles in the specialization of cells in the retina (the light-sensitive tissue that lines the back of the eye) and the formation of blood vessels in the retina and in the inner ear.
Conditions referring to this gene or chromosome
Otros nombres
ND
NDP_HUMAN
Norrie disease (pseudoglioma)
norrin
Related patient information and medicines
Patient information leaflet
Cáncer de mama
Most develop en women over the age of 50 but younger women are sometimes affected. Breast cancer develops from a cancerous (malignant) cell which develops in the lining of a duct or lobule in one of the breasts. Breast cancer can also develop in men, although this is much less common than breast cancer in women. Anatomy of the breasts Breast.
Patient information leaflet
Cáncer de boca
Mouth cancer can affect any part of the mouth, including the tongue and lips. The most common symptoms are having a sore or ulcer for more than three weeks. You should see your dentist or doctor if you have any symptoms in your mouth that are unusual. The outlook (prognosis) for people with mouth cancer is good if it is diagnosed early. What is.
Patient information leaflet
síndrome de Turner
síndrome de Turner chromosomes Girls and women with Turner syndrome have only one X chromosome. The karyotype is therefore said to be 45,X or 45,XO. How common is Turner syndrome. Turner syndrome occurs in about one in 2,000 live female births. There are no known risk factors for Turner syndrome. It is not more common in girls born to older women and.
Patient information leaflet
Rodillas en X
Rodillas en X describes an unusual angle of the lower legs. Most commonly it is a normal shape as children's legs develop, but occasionally in children or adults it can cause problems or have an underlying cause. Most children who have knock knees grow out of the condition. What are knock knees. The medical term for knock knees is 'genu valgum' -.
Patient information leaflet
¿Puedo tomar melena de león y matcha juntos?
In fact, man... However, because both substances can affect the brain and nervous system, some people may feel overly stimulated or experience a mild upset stomach. Why this happens Lion's Mane is thought to stimulate 'nerve growth factor' (NGF) to support brain health, while matcha contains caffeine and L-theanine which improve alertness and.
Patient information leaflet
¿Puedo tomar Ciprofloxacino y Doxiciclina juntos?
Taking ciprofloxacin and doxycycline together may slightly aumentar el risk of side effects, such as skin sensitivity to sunlight or digestive upset. Doxycycline stops bacteria from growing (bacteriostatic), while ciprofloxacin actively kills them (bactericidal). Always consult your GP, pharmacist, or another qualified healthcare professional.
Lecturas adicionales y referencias
- norrin cystine knot growth factor NDP; MedlinePlus, National Library of Medicine.
- Chen ZY, Hendriks RW, Jobling MA, Powell JF, Breakefield XO, Sims KB, Craig IW. Isolation and characterization of a candidate gene for Norrie disease. Nat Genet. 1992 Jun;1(3):204-8. doi: 10.1038/ng0692-204.
- Clevers H. Wnt signaling: Ig-norrin the dogma. Curr Biol. 2004 Jun 8;14(11):R436-7. doi: 10.1016/j.cub.2004.05.039.
- Dickinson JL, Sale MM, Passmore A, FitzGerald LM, Wheatley CM, Burdon KP, Craig JE, Tengtrisorn S, Carden SM, Maclean H, Mackey DA. Mutations in the NDP gene: contribution to Norrie disease, familial exudative vitreoretinopathy and retinopathy of prematurity. Clin Exp Ophthalmol. 2006 Sep-Oct;34(7):682-8. doi: 10.1111/j.1442-9071.2006.01314.x.
- Haider MZ, Devarajan LV, Al-Essa M, Kumar H. A C597-->A polymorphism in the Norrie disease gene is associated with advanced retinopathy of prematurity in premature Kuwaiti infants. J Biomed Sci. 2002 Jul-Aug;9(4):365-70. doi: 10.1007/BF02256593.
- Hiraoka M, Berinstein DM, Trese MT, Shastry BS. Insertion and deletion mutations in the dinucleotide repeat region of the Norrie disease gene in patients with advanced retinopathy of prematurity. J Hum Genet. 2001;46(4):178-81. doi: 10.1007/s100380170085.
- Kondo H, Qin M, Kusaka S, Tahira T, Hasebe H, Hayashi H, Uchio E, Hayashi K. Novel mutations in Norrie disease gene in Japanese patients with Norrie disease and familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci. 2007 Mar;48(3):1276-82. doi: 10.1167/iovs.06-1042.
- Royer G, Hanein S, Raclin V, Gigarel N, Rozet JM, Munnich A, Steffann J, Dufier JL, Kaplan J, Bonnefont JP. NDP gene mutations in 14 French families with Norrie disease. Hum Mutat. 2003 Dec;22(6):499. doi: 10.1002/humu.9204.
- Scruggs BA, Reding MQ, Schimmenti LA. NDP-Related Retinopathies. 1999 Jul 30 [updated 2023 Mar 23]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1331/
- Shastry BS. Genetic susceptibility to advanced retinopathy of prematurity (ROP). J Biomed Sci. 2010 Aug 25;17(1):69. doi: 10.1186/1423-0127-17-69.
- Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell. 2004 Mar 19;116(6):883-95. doi: 10.1016/s0092-8674(04)00216-8.
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.