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Macitentan para la hipertensión arterial pulmonar

Opsumit

Macitentan will be prescribed for you by a specialist doctor.

Take one 10 mg tablet each day. Swallow the tablet whole with a drink of water.

Common side-effects include respiratory infections and feeling tired or dizzy.

De un vistazo

  • Macitentan is a medicine for adults with pulmonary hypertension.

  • It widens blood vessels in the lungs, reducing pressure and improving blood flow.

  • Take one tablet daily, with or without food.

  • Women of childbearing potential must use effective contraception due to pregnancy risks.

  • Report any signs of liver damage to your doctor immediately.

  • Common side-effects include infections, headache, and feeling tired.

About macitentan

Tipo de medicamento

Un medicamento antihipertensivo vasodilatador

Usado para

Hipertensión pulmonar

También llamado

Opsumit®

Disponible como

Comprimidos

Hipertensión arterial pulmonar (HAP) is a condition where there is too high a blood pressure in the arteries which supply blood to your lungs from your heart. The arteries become narrowed so your heart has to work harder to pump blood to your lungs.

Macitentan relaxes the muscles in the walls of the arteries, allowing the blood vessels to become wider. This reduces the pressure in the arteries and allows blood to flow more easily through them. In turn, this increases the supply of blood to your lungs and improves your ability to do physical activities. Macitentan will be prescribed for you by a doctor who is a specialist.

Before taking macitentan

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking macitentan it is important that your doctor knows:

  • Si tienes algún problema con el funcionamiento de tu hígado, o si tienes algún problema con el funcionamiento de tus riñones.

  • If you have been told you have a reduced number of red blood cells (anaemia).

  • Si estás embarazada, intentando concebir o amamantando.

  • If you have ever had an allergic reaction to a medicine, or if you are allergic to soya.

  • Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.

How to take macitentan tablets

  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack, along with any information you have been given by your hospital. The manufacturer's leaflet will give you more information about macitentan and a full list of side-effects which you may experience from taking it.

  • Take macitentan exactly as your doctor tells you to. The usual dose is one 10 mg tablet daily. Try to take your doses at the same time of day each day, as this will help you to remember to take the tablets regularly.

  • Swallow the tablet whole with a drink of water. You can take macitentan either before or after food.

  • If you forget to take a dose at your usual time, take it as soon as you remember. If you do not remember until the following day, skip the forgotten dose. Do not take two doses at the same time to make up for a missed dose.

Obteniendo el máximo de tu tratamiento

  • Try to keep your regular appointments with your doctor so your progress can be checked. Your doctor will want you to have some blood tests both before and during your treatment. The tests will check that your liver is staying healthy.

  • Treatment with macitentan is usually long-term. Continue to take the tablets unless you are advised otherwise.

  • If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable for you to take. The herbal medicine called St John's wort can interfere with macitentan so you should not take preparations containing this ingredient.

  • If you are due to have an operation or some other medical treatment, it is important that you tell the person carrying out the treatment that you are on macitentan.

  • Women with pulmonary hypertension should avoid becoming pregnant as pregnancy can lead to serious worsening of your condition. Women of childbearing potential must use effective contraception during treatment with macitentan. Speak with your doctor about which contraceptive methods are suitable for you.

Can macitentan tablets cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with macitentan. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Very common macitentan side-effects

(estos afectan a más de 1 de cada 10 personas)

¿Qué puedo hacer si experimento esto?

Mouth, throat and chest infections

If troublesome, speak with your doctor for advice

Dolor de cabeza

Drink plenty of water and ask your doctor or pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know

Feeling tired (due to anaemia)

If troublesome, speak with your doctor for advice. Do not drive and do not use tools or machines while affected

Fluid retention and swelling of ankles or feet

Try raising your feet when sitting down and avoid wearing tight socks or stockings. If troublesome, speak with your doctor for advice

Common macitentan side-effects

(estos afectan a menos de 1 de cada 10 personas)

¿Qué puedo hacer si experimento esto?

Sensación de mareo

This could be a symptom of your condition or a side-effect of using macitentan. If you begin to feel dizzy, sit or lie down for a few minutes so you do not faint, and then get up more slowly. Do not drive and do not use tools or machines while affected

Flu-like symptoms, feeling hot or flushed and urine infections

If troublesome, speak with your doctor for advice

Blocked nose (nasal congestion)

Try a steam inhalant such as menthol crystals or eucalyptus oil or ask a pharmacist for advice. Avoid taking decongestant medicines, such as pseudoephedrine, as these may affect your medical condition

Importante: your doctor will discuss with you the possibility that your medicine could cause damage to your liver. If you experience any of the following you should let your doctor know straightaway so that it can be investigated:

  • Pérdida de apetito

  • Extreme tiredness

  • Dark urine

  • Picazón

  • Yellowing of your skin or the whites of your eyes (jaundice)

  • Constantly feeling sick (nausea) or being sick (vomiting)

  • Pain in your tummy (abdomen)

These are signs that your liver could be being damaged and your doctor will want you to have a blood test to check for this.

Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, por favor hable con su médico o farmacéutico para obtener más consejos.

How to store macitentan

  • Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Información importante sobre todos los medicamentos

Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.

Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.

No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.

Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.

Informar efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

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¿Inseguro sobre mezclar medicamentos?

Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.

Preguntas frecuentes

What is the specific type of blood pressure macitentan helps with?

Macitentan is used to treat pulmonary arterial hypertension (PAH), which is high blood pressure specifically in the arteries that carry blood from your heart to your lungs.

How does macitentan work to improve my condition?

Macitentan works by relaxing the muscles in the walls of your lung arteries. This causes the blood vessels to widen, which reduces the pressure in the arteries and allows blood to flow more easily to your lungs. This improved blood flow helps you perform physical activities more easily.

Who will prescribe macitentan for me?

Macitentan will be prescribed for you by a doctor who is a specialist in conditions like pulmonary hypertension.

Can I take macitentan if I am allergic to soya?

If you are allergic to soya, it is important to inform your doctor before you start taking macitentan. They will assess if the medicine is suitable for you.

Why is it important to tell my doctor if I take other medicines, including herbal ones?

It's important because some medicines are not suitable to be taken together, and others may require extra care. For example, the herbal medicine St John's wort can interfere with macitentan, so you should not take preparations containing it.

How should I manage pregnancy risk while on macitentan?

Women with pulmonary hypertension should avoid becoming pregnant as it can seriously worsen your condition. If you are of childbearing potential, you must use effective contraception throughout your treatment with macitentan. Discuss suitable contraceptive methods with your doctor.

What should I do if I feel dizzy while taking macitentan?

If you start to feel dizzy, sit or lie down for a few minutes to prevent fainting, then get up slowly. You should not drive or operate tools or machines if you are feeling dizzy. This symptom could be related to your condition or a side-effect of the medication.

Lecturas adicionales y referencias

Sobre el autorVer biografía completa

Imagen del autor

Michael Stewart, MRPharmS

Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico

BPharm (Hons), MRPharmS

Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.

Acerca del revisor

Imagen del autor

Sid Dajani

Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.

Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • Siguiente revisión prevista: 23 de junio de 2027
  • 21 Jun 2024 | Última versión

    Última actualización por

    Michael Stewart, MRPharmS

    Revisado por pares por

    Sid Dajani
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