Capsulas y gotas de Alfacalcidol
One-Alpha
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 23 de agosto de 2024
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Alfacalcidol is a type of vitamin D.
You will need to have regular blood tests while you are taking the medicine so that your doctor can adjust your dose.
Make sure you know the symptoms of too much calcium in your blood - these are losing your appetite, feeling thirsty, being sick (vomiting), feeling tired and losing weight. Please let your doctor know if you develop these symptoms.
De un vistazo
Alfacalcidol is a type of vitamin D that helps regulate calcium and phosphate for healthy bones.
It is particularly useful for people with kidney problems because it does not need activation by the kidneys.
It is available as capsules, oral drops, and injections.
Take alfacalcidol exactly as your doctor tells you, usually once a day.
Your doctor will monitor your calcium levels with blood tests and adjust your dose as needed.
See your doctor if you experience loss of appetite, thirst, or frequent urination, as these may signal too much calcium.
About alfacalcidol
Tipo de medicamento | A type of vitamin D |
Usado para | To promote healthy bones |
También llamado | One-Alpha®; AlfaD®;AlciDol®; AlfacalEss®; |
Disponible como | Capsules, oral drops and injection |
Alfacalcidol is a type of vitamin D. Vitamin D helps to regulate the amount of calcium and phosphate in your body. All three of these substances are important for maintaining healthy, strong bones and teeth.
There are several types of vitamin D available but most other types need 'activating' by the kidneys. Alfacalcidol is a form of vitamin D which does not need this activation process, and so it is particularly helpful for people who need their bones strengthening but who also have kidney problems. You may also need to take mineral supplements along with alfacalcidol.
Alfacalcidol is available as capsules, as oral liquid drops and also as an injection.
Before taking alfacalcidol
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking alfacalcidol it is important that your doctor knows:
Si estás embarazada o amamantando.
If you have ever had kidney stones or you have other problems with your kidneys.
If you know you have too much calcium in your blood or urine. This can happen with some cancers.
If you have any heart problems.
If you have an allergy to sesame oil (used in One-Alpha® capsules).
If you have been told you have sarcoidosis or other rare, 'granulomatous' disease.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take alfacalcidol
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about alfacalcidol and will provide you with a full list of the side-effects which you may experience from taking it.
Take alfacalcidol exactly as your doctor tells you to. It is usually taken as one dose a day. Try to take your doses at the same time of day each day, as this will help you to remember to take it regularly.
There are three strengths of capsule and one strength of oral drop available - your doctor will tell you what dose to take each day. Your dose could change from time to time depending upon the results of your routine blood tests.
Si olvida tomar una dosis, tómela tan pronto como lo recuerde. Si no lo recuerda hasta el día siguiente, omita la dosis olvidada. No tome dos dosis juntas para compensar una dosis olvidada.
Directions for using One-Alpha® drops
Nota: each drop contains 0.1 microgram (100 nanograms) of alfacalcidol.
Remove the bottle cap. (Do reportado shake the bottle before using.) You will see a dropper which is ready for you to use.
Hold the bottle upside down so that a drop appears at the end of the dropper. If a drop doesn't form, tap the bottle gently with a finger so that it does.
Let the drop fall into your (or your child's) mouth, or catch it on a spoon if this is easier. Your doctor will tell you how many drops to take - count these out carefully to make sure that you (or your child) take the correct number.
Obteniendo el máximo de tu tratamiento
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want you to have regular blood tests during the treatment to check on the amount of calcium in your blood. Your dose of alfacalcidol will be adjusted as a result of having these tests.
Treatment with alfacalcidol may be for short periods of time (such as in preparation for surgery), or could be long-term. Please continue to take alfacalcidol regularly unless you are told otherwise by your doctor.
Can alfacalcidol cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Alfacalcidol occasionally causes skin rashes but other side-effects could be due to too much calcium being in your blood (see the table below). You will find a full list of side-effects in the manufacturer's information leaflet supplied with your medicine. Please speak with your doctor or pharmacist if any of the following continue or become troublesome.
Alfacalcidol side-effects | ¿Qué puedo hacer si experimento esto? |
Skin rash and itchiness | Si es problemático, hable con su médico |
Sensación de mareo | Do not drive and do not use tools or machines until you are feeling better |
Loss of appetite, loss of weight, feeling tired, feeling sick (nausea), feeling thirsty, sweating, a metallic taste in your mouth, a need to pass urine more often | These are signs that there could be too much calcium in your blood. Make an appointment to see your doctor as soon as possible. Your dose may need adjusting or your treatment with alfacalcidol may need to be stopped for a few days |
If you experience any other symptoms which you think may be due to alfacalcidol, please speak with your doctor or pharmacist for further advice.
How to store alfacalcidol
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Capsules should be stored in a cool, dry place, away from direct heat and light.
Oral drops should be kept refrigerated once the bottle has been opened. Do not use or keep an opened bottle for longer than 28 days.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
Si compras algún medicamento, consulta con un farmacéutico que sean adecuados para tomar con tus otros medicamentos.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What is the difference between alfacalcidol and other forms of vitamin D?
Alfacalcidol is a unique form of vitamin D because it does not require activation by the kidneys. Most other types of vitamin D need this activation process. This makes alfacalcidol particularly useful for individuals who need to strengthen their bones but also have existing kidney problems.
Why do I need regular blood tests when taking alfacalcidol?
Regular blood tests are important because your doctor needs to monitor the amount of calcium in your blood. The dosage of alfacalcidol may be adjusted based on these test results to ensure it remains effective while preventing too much calcium from building up.
How long will I need to take alfacalcidol?
The duration of your alfacalcidol treatment can vary. It may be prescribed for short periods, for example, in preparation for surgery. Alternatively, it could be a long-term treatment. You should continue to take it regularly unless your doctor advises you otherwise.
What should I do if I notice signs of too much calcium in my blood?
If you experience symptoms such as loss of appetite, weight loss, tiredness, nausea, increased thirst, sweating, a metallic taste in your mouth, or needing to urinate more frequently, these could indicate too much calcium in your blood. You should contact your doctor as soon as possible for advice, as your dose may need adjustment or your treatment might be temporarily stopped.
Are there any specific storage instructions for alfacalcidol oral drops after opening?
Yes, once an opened bottle of alfacalcidol oral drops should be kept refrigerated. It should not be used or stored for longer than 28 days after opening.
Lecturas adicionales y referencias
- Manufacturer's PIL, One-Alpha® Capsules; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated February 2022.
- Manufacturer's PIL, One-Alpha® oral drops; Neon Healthcare Ltd, The electronic Medicines Compendium. Dated February 2022.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Siguiente revisión prevista: 25 de agosto de 2027
23 de agosto de 2024 | Última versión

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