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Hydroxocobalamin injection

Cobalin-H, Neo-Cytamen

Hydroxocobalamin is used to treat some types of anaemia.

It is given by injection into a muscle.

Treatment with hydroxocobalamin is usually lifelong.

At a glance

  • Hydroxocobalamin is a form of vitamin B12, given as an injection.

  • It treats anaemia caused by a lack of vitamin B12, often due to pernicious anaemia.

  • It is also used for some rare eye conditions.

  • Injections are given into a muscle, initially every 2-3 days, then every 2-3 months.

  • Tell your doctor if you are pregnant, breastfeeding, or allergic to cobalt.

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About hydroxocobalamin

Tipo de medicamento

Vitamin B12 replacement

Usado para

Anaemia caused by lack of vitamin B12, and some rare eye conditions

También llamado

Cobalin-H®; Neo-Cytamen®

Disponible como

Inyección

The most common cause of vitamin B12 deficiency in the UK is a condition called pernicious anaemia. This is a condition where insufficient amounts of vitamin B12 are absorbed into your body from the food you eat. This can be because you are not able to absorb it properly, or because you have had surgery which has removed part of your digestive system. This type of anaemia is easily treated by having regular injections of hydroxocobalamin, which is a form of vitamin B12.

Hydroxocobalamin is also occasionally used for some rare eye conditions.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start having hydroxocobalamin injections it is important that your doctor knows:

  • If you are pregnant or breastfeeding. (Hydroxocobalamin is not known to be harmful to an unborn baby or while breastfeeding, but nevertheless you should let your doctor know about this.)

  • If you know you have an allergy to cobalt.

  • Si alguna vez has tenido una reacción alérgica a un medicamento.

  • Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.

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  • Hydroxocobalamin will usually be given to you by your doctor or nurse. It will be given by injection into a muscle.

  • When you first start treatment, you will need to have an injection every 2-3 days. This is to top up the store of vitamin B12 in your body. After a few weeks, you will only need to have one injection every 2-3 months. Your doctor will tell you when to arrange an appointment for you to have these injections. If ever you miss an appointment, you should contact your doctor's surgery to make another appointment as soon as possible so that you receive your injections on time.

  • Before you start this treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about treatment with hydroxocobalamin.

  • Try to keep your regular doctor's appointments so that your progress can be checked. You may need to have some blood tests from time to time, particularly at the beginning of your treatment. The tests will check that the treatment is working, and will also check on the amount of potassium in your blood, as this may drop a little initially.

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Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. The table below lists some of the most common ones associated with hydroxocobalamin injections. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve in the first few days after having the injection, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Hydroxocobalamin side-effects

¿Qué puedo hacer si experimento esto?

Sentirse mal (náuseas)

Mantente en comidas simples - evita alimentos ricos o picantes

Dolor de cabeza

Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, consulta a tu médico

Sensación de mareo

If this happens, do not drive and do not use tools or machines until you feel well again

High temperature (fever), rash, itching or pain where you were injected

Let your doctor or nurse know about these

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor, nurse or pharmacist.

  • Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

If you are having an operation or dental treatment tell the person carrying out the treatment which medicines you are taking.

Si compras algún medicamento, consulta con un farmacéutico que sean adecuados para tomar con tus otros medicamentos.

No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.

Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.

Informar efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

verificador de síntomas

¿Inseguro sobre mezclar medicamentos?

Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.

Preguntas frecuentes

What is pernicious anaemia and how does it relate to hydroxocobalamin?

Pernicious anaemia is the most common reason for vitamin B12 deficiency in the UK. With this condition, your body doesn't properly absorb vitamin B12 from food. Hydroxocobalamin, a form of vitamin B12, is given as regular injections to treat this type of anaemia.

How long will I need to have hydroxocobalamin injections?

Initially, you will receive injections every 2-3 days to build up your body's vitamin B12 stores. After a few weeks, this will reduce to one injection every 2-3 months on an ongoing basis. Your doctor will advise you on the exact schedule and when to book follow-up appointments.

Are there any reasons why I might not be able to have hydroxocobalamin injections?

Yes, it's important to tell your doctor if you have an allergy to cobalt or if you've had an allergic reaction to any medicine before. While generally considered safe during pregnancy and breastfeeding, you should still inform your doctor if either applies to you.

What should I do if I miss an appointment for my hydroxocobalamin injection?

If you miss an appointment for your injection, you should contact your doctor's surgery as soon as possible. It's important to make another appointment quickly so that you receive your injections on time and maintain your treatment schedule.

What are the common side-effects of hydroxocobalamin and what can I do about them?

Common side-effects include feeling sick (nausea), headaches, feeling dizzy, or a high temperature, rash, itching, or pain at the injection site. For nausea, try eating simple meals. For headaches, drink water and ask a pharmacist for a suitable painkiller. If you feel dizzy, avoid driving or using machinery. If any side-effects continue or become bothersome, or if you experience a high temperature, rash, itching or pain at the injection site, speak with your doctor or nurse.

Will I need any tests while I'm having hydroxocobalamin treatment?

Yes, you might need to have blood tests periodically, especially when you first start treatment. These tests help ensure that the treatment is working effectively and will also check your blood potassium levels, as these can sometimes drop slightly at the beginning of treatment.

Can hydroxocobalamin affect other medicines I'm taking?

The article doesn't specify if hydroxocobalamin interacts with other medicines, but it states that you should inform your doctor about all medicines you are taking, including any bought without a prescription, herbal remedies, and complementary medicines. Also, if you buy any new medicines, you should check with a pharmacist if they are suitable to take with your current medication.

Lecturas adicionales y referencias

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

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Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • Próxima revisión: 11 Jun 2027
  • 12 Dic 2022 | Última versión

    Última actualización por

    Michael Stewart, MRPharmS

    Revisado por pares por

    Sid Dajani
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