Can I take Omeprazole and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking omeprazole and sertraline together can increase the amount of sertraline in your bloodstream. This may increase the risk of side effects from sertraline, such as feeling sick (nausea), tremors, sleep problems, or feeling agitated. In rare cases, it could lead to a serious condition called serotonin syndrome, which causes high body temperature, sweating, and confusion.
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Why this happens
Sertraline is broken down in the liver by certain proteins (enzymes). Omeprazole can slow down these proteins, which means the sertraline stays in your body longer and reaches higher levels than intended.
What you should do
You can take these medicines together, but you should be aware of increased side effects. If you notice you are feeling more anxious, shaky, or unwell after starting omeprazole, speak to your doctor. They may suggest a lower dose of sertraline or a different type of indigestion medicine (like famotidine or lansoprazole) that is less likely to interfere.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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