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Can I take Atorvastatin and Ezetimibe together?

Guía de interacción de medicamentos

Taking atorvastatin and ezetimibe together is a common and effective way to lower cholesterol. However, combining these two medicines slightly increases the risk of muscle-related side effects, such as muscle pain, tenderness, or weakness. In very rare cases, this can lead to a serious condition called rhabdomyolysis, where muscle tissue breaks down and can cause kidney damage.

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Por qué sucede esto

Both medicines work in different ways to lower cholesterol (atorvastatin stops the liver from making it, while ezetimibe stops the gut from absorbing it). Because both drugs can independently affect muscle tissue, taking them together has an 'additive' effect, meaning the small risk associated with each drug is combined.

It is generally safe to take these together if prescribed by your doctor. You should monitor yourself for any unexplained muscle pain, tenderness, or weakness, especially when you first start the treatment or if your dose is increased. If you notice these symptoms, or if your urine becomes dark in colour, contact your doctor immediately.

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Embarazo

You must not take these medicines if you are pregnant or planning to become pregnant, as they can cause serious harm to an unborn baby. Use effective contraception while taking these medicines.

Muscle disorders

Busque atención médica inmediata si experimenta dolor, sensibilidad o debilidad muscular inexplicables. En casos raros, esto puede conducir a una condición grave llamada rabdomiólisis que causa daño renal.

Jugo de toronja

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While there is no direct 'chemical' interaction, both these medicines and alcohol can affect your liver. Drinking large amounts of alcohol regularly while taking these medicines can increase the risk of liver problems. It is best to stay within the recommended UK low-risk guidelines (no more than 14 units per week).

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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