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Can I take Danazol and Sertraline together?

Drug interaction guide

Taking danazol and sertraline together may increase the risk of a rare but serious condition called serotonin syndrome. It can also increase the levels of sertraline in your blood, potentially leading to more side effects.

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Why this happens

Danazol can slow down the way your liver breaks down sertraline (by affecting enzymes like CYP3A4). This leads to higher levels of sertraline in your body. Additionally, both drugs can influence serotonin levels, which may lead to an over-accumulation of this chemical in the brain.

What you should do

You should speak to your doctor before taking these two medicines together. If your doctor decides this combination is necessary, they may need to adjust your dose. Seek medical help immediately if you experience symptoms like shivering, sweating, a very high temperature, a fast heartbeat, muscle stiffness, or confusion.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • 25 Enero 2026 | Publicado originalmente
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