Can I take Alogliptin and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
Satisface las necesidades del paciente directrices editoriales
- DescargarDescargar
- Compartir
- Idioma
- Debate
Taking alogliptin and Rybelsus (semaglutide) together can significantly increase the risk of your blood sugar dropping too low (hypoglycaemia). Additionally, both medicines work in a similar way on the same hormonal pathway, and using them together is generally not recommended because it does not provide extra benefit but increases the risk of side effects.
En este artículo:
Seguir leyendo
Why this happens
Both drugs target the 'incretin' system. Alogliptin (a DPP-4 inhibitor) prevents the breakdown of natural hormones that lower blood sugar, while Rybelsus (a GLP-1 receptor agonist) mimics those same hormones. Using both is like 'doubling up' on the same biological process, which can lead to an over-correction of blood sugar levels.
What you should do
You should speak to your doctor or pharmacist before taking these together. Clinical guidelines usually recommend stopping the DPP-4 inhibitor (alogliptin) when starting a GLP-1 medicine like Rybelsus. If your doctor has specifically told you to take both, be very alert for signs of low blood sugar, such as feeling shaky, sweaty, dizzy, or hungry.
Seguir leyendo
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Tratamiento y medicación
Can I take Magnesium and Bisoprolol together?
Taking magnesium and bisoprolol together can lead to an excessively slow heart rate or a significant drop in blood pressure. This may cause you to feel dizzy, lightheaded, or faint.
Tratamiento y medicación
Can I take Atorvastatin and Levothyroxine together?
Taking these two medicines together is generally safe, but there is a minor interaction where atorvastatin might slightly increase the levels of levothyroxine in your blood. Conversely, your thyroid levels can affect how well atorvastatin works to lower your cholesterol.
Seguir leyendo
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
Pregunte, comparta, conecte.
Explore debates, formule preguntas y comparta experiencias sobre cientos de temas de salud.
¿Se encuentra mal?
Evalúe sus síntomas en línea de forma gratuita
Suscríbase al boletín informativo para pacientes.
Tu dosis semanal de consejos de salud claros y fiables, redactados para ayudarte a sentirte informado, seguro y en control.
Al suscribirte, aceptas nuestra Política de privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.