Can I take Magnesium and Solifenacin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking magnesium (especially as an antacid) at the same time as solifenacin may slow down how quickly your body absorbs the solifenacin. This could potentially delay how well the medicine works for your bladder symptoms. Additionally, both substances can affect how your bowels work; solifenacin often causes constipation, while some forms of magnesium can cause diarrhoea or, conversely, certain antacids can worsen constipation.
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Why this happens
Magnesium-containing antacids can increase the pH level in the stomach and physically bind to other drugs, which slows down the rate at which solifenacin enters the bloodstream. There is also a minor 'pharmacodynamic' overlap where both drugs affect the digestive system in opposite or unpredictable ways.
What you should do
You can usually take both, but it is best to space them out. Try to take your solifenacin at least 2 hours before or 4 to 6 hours after taking a magnesium supplement or antacid. If you notice your bladder symptoms are not being controlled as well as usual, or if you suffer from severe constipation, speak with your pharmacist or doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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