Can I take Magnesium and Vitamin B2 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known negative interaction between magnesium and vitamin B2 (riboflavin). In fact, they are often taken together because they work well as a team in the body.
Why this happens
Magnesium and vitamin B2 do not interfere with each other's absorption or metabolism. Instead, they have a 'synergistic' effect, meaning they help each other work. For example, magnesium is required for the body to properly use certain vitamins, and both are involved in the same energy-production processes within your cells.
What you should do
It is safe to take these two supplements together. They are frequently combined in a single tablet, particularly for people trying to prevent migraines. As with any supplement, stick to the recommended daily dose on the packaging unless your doctor tells you otherwise.
Important precautions
Kidney disease
If you have severe kidney problems, your body may not be able to remove excess magnesium, leading to dangerously high levels in the blood. Check with your doctor before use.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking magnesium. Alcohol acts as a diuretic, which can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective. Additionally, chronic alcohol use can lead to magnesium deficiency.
It is best to avoid or strictly limit alcohol when taking Vitamin B2. Alcohol can interfere with the way your body absorbs this vitamin from the digestive tract, making the supplement less effective.
Dairy products (Milk, Cheese, Yoghurt)
Avoid taking magnesium supplements at the same time as large amounts of dairy products. Dairy is high in calcium, and high doses of calcium can compete with magnesium for absorption in the gut, meaning you may not get the full benefit of your supplement. It is best to space them at least 2 hours apart.
Caffeine (Coffee, Tea, Energy drinks)
It is best to limit caffeine intake around the time you take magnesium. Like alcohol, caffeine has a mild diuretic effect and can increase the excretion of magnesium through the kidneys.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Naproxen and Tramadol together?
Taking naproxen and tramadol together can increase the risk of serious side effects, particularly affecting your stomach and kidneys. There is also a small but important risk of seizures (fits) and a rare condition called serotonin syndrome. However, these two medicines are often prescribed together for short-term pain relief under medical supervision.

Drug interactions checker
Can I take Losartan and Vitamin D together?
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Aquipta and Naproxen together?
- Can I take Aspirin and Nustendi together?
- Can I take Atorvastatin and Bisoprolol together?
- Can I take Atorvastatin and Fibre supplements together?
- Can I take Atorvastatin and Maitake together?
- Can I take Chaga and Maitake together?
- Can I take Codeine and Ibuprofen together?
- Can I take Colecalciferol and Esomeprazole together?
- Can I take Evana heavy period relief and Mefenamic acid together?
- Can I take Ginger and Vitamin B complex together?
- Can I take Iron supplements and Wellbutrin together?
- Can I take Levothyroxine and Paracetamol together?
- Can I take Losartan and Trazodone together?
- Can I take Mounjaro and Paracetamol together?
- Can I take Oestrogel pump-pack and Vitamin B2 together?
- Can I take Omeprazole and Viagra together?
- Can I take Pyridostigmine and Ramipril together?
- Can I take Sertraline and Fluoxetine together?
- Can I take St John's wort and Contraceptive pill together?
- Can I take Warfarin and Amoxicillin together?