Can I take Aspirin and Omeprazole together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together is generally safe and often beneficial. Omeprazole can actually help protect your stomach from the irritation or ulcers that aspirin sometimes causes. However, omeprazole might slightly change how quickly or how well your body absorbs certain types of aspirin (like enteric-coated tablets).
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Why this happens
Omeprazole reduces the amount of acid in your stomach. Some aspirin tablets have a special coating (enteric coating) designed to dissolve only when they reach the gut. By making the stomach less acidic, omeprazole might cause this coating to break down too early in the stomach, or it may slightly alter how the aspirin is absorbed into the bloodstream. Despite this, the overall effect of the aspirin is usually not changed enough to be a concern.
What you should do
You can take these medicines together. In fact, doctors often prescribe them together specifically to protect the stomach lining if you need to take aspirin long-term. If you are taking aspirin to prevent heart problems or strokes, continue to take it as prescribed. If you notice any unusual stomach pain or indigestion, mention it to your pharmacist or doctor.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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