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Can I take Aspirin and Omeprazole together?

Guía de interacción de medicamentos

Taking these two medicines together is generally safe and often beneficial. Omeprazole can actually help protect your stomach from the irritation or ulcers that aspirin sometimes causes. However, omeprazole might slightly change how quickly or how well your body absorbs certain types of aspirin (like enteric-coated tablets).

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Por qué sucede esto

Omeprazole reduces the amount of acid in your stomach. Some aspirin tablets have a special coating (enteric coating) designed to dissolve only when they reach the gut. By making the stomach less acidic, omeprazole might cause this coating to break down too early in the stomach, or it may slightly alter how the aspirin is absorbed into the bloodstream. Despite this, the overall effect of the aspirin is usually not changed enough to be a concern.

You can take these medicines together. In fact, doctors often prescribe them together specifically to protect the stomach lining if you need to take aspirin long-term. If you are taking aspirin to prevent heart problems or strokes, continue to take it as prescribed. If you notice any unusual stomach pain or indigestion, mention it to your pharmacist or doctor.

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Asma

Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening allergic reaction or asthma attack.

Embarazo (tercer trimestre)

Do not take aspirin during the last 3 months of pregnancy unless specifically prescribed by a specialist, as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.

Diarrea severa

Contact your doctor immediately if you develop severe or persistent watery diarrhoea; omeprazol can increase your risk of a serious bowel infection caused by Clostridium difficile.

Alcohol

Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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