Can I take Cordyceps and Shiitake together?

Why this happens

These mushrooms have 'additive' effects. This means they work in similar ways: both contain compounds that can prevent platelets (blood cells) from sticking together to form clots, and both can increase insulin sensitivity or mimic insulin's effect on blood sugar.

It is generally safe for healthy individuals to consume these together in culinary amounts. However, if you are taking supplements, you should monitor for signs of easy bruising or bleeding gums. If you have diabetes or are taking blood-thinning medication (like warfarin or aspirin), consult your doctor before combining these supplements, as your dosages may need adjusting.

Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)

These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.

Bleeding disorders or upcoming surgery

Both supplements may slow blood clotting and increase the risk of bleeding during and after surgery. You must stop taking them at least 2 weeks before any scheduled surgical procedure.

Diabetes (on medication)

These supplements can lower blood sugar levels. When taken with insulin or other diabetes medicines, they may cause your blood sugar to drop dangerously low (hypoglycaemia).

Shiitake dermatitis

Eating raw or undercooked shiitake can cause a severe, itchy, whip-like skin rash (flagellate dermatitis) in sensitive individuals due to a reaction to lentinan.

Alcohol

It is best to avoid or strictly limit alcohol when taking these supplements. Both cordyceps and shiitake may have effects on the liver or blood sugar levels, and alcohol can increase the risk of liver strain or cause unpredictable changes in blood sugar.

Caffeine (Coffee, Tea, Energy Drinks)

Cordyceps may have mild stimulant properties. Consuming caffeine alongside this supplement may increase feelings of jitteriness, rapid heartbeat, or difficulty sleeping.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.