Can I take Citalopram and Simvastatin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking citalopram and simvastatin together may slightly increase the levels of simvastatin in your blood. This can increase the risk of side effects, particularly muscle pain or weakness.
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Why this happens
Both drugs are processed by the liver. Citalopram can mildly interfere with the enzymes (specifically CYP3A4 and CYP2C19) that break down simvastatin, leading to a small rise in simvastatin levels.
What you should do
You can usually take these together, but you should be aware of the signs of 'statin' side effects. If you experience unexplained muscle pain, tenderness, or weakness, contact your doctor. Your doctor may choose to monitor you more closely or adjust your simvastatin dose if you are on a high dose (such as 80mg).
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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