Can I take Bisoprolol and Rybelsus together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking bisoprolol and Rybelsus (semaglutide) together can make it harder for you to notice the warning signs of low blood sugar (hypoglycaemia). Bisoprolol can hide symptoms like a fast heartbeat, palpitations, or tremors. Additionally, bisoprolol may slightly interfere with how your body manages blood sugar levels, potentially making Rybelsus less effective or, in some cases, increasing the risk of a 'hypo'.
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Why this happens
Bisoprolol is a beta-blocker that works by slowing the heart rate and blocking the effects of adrenaline. Adrenaline is the hormone responsible for the 'shaky' feeling and racing heart you get when your blood sugar drops too low. By blocking these signals, the drug 'masks' the symptoms of low blood sugar. Furthermore, beta-blockers can sometimes interfere with the release of insulin and the body's ability to release stored sugar from the liver.
What you should do
You can take these medicines together, but you should be extra vigilant. Since you may not feel a racing heart if your blood sugar drops, look out for other signs of a 'hypo' that bisoprolol doesn't mask, such as sweating, dizziness, hunger, or confusion. It is a good idea to monitor your blood sugar levels more frequently when starting or changing the dose of either medication. Discuss a plan with your doctor or pharmacist on what to do if your blood sugar levels become unstable.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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