transforming growth factor beta receptor 1
Última actualización 2 de mayo de 2023
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
El TGFBR1 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 1. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division.
Normal function
El TGFBR1 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 1. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division.
To carry out its signaling function, TGF-β receptor type 1 spans the cell membrane, so that one end of the protein projects from the outer surface of the cell (the extracellular domain) and the other end remains inside the cell (the intracellular domain). A protein called TGF-β attaches (binds) to the extracellular domain of TGF-β receptor type 1, which turns on (activates) the receptor and allows it to bind to another receptor on the cell surface. These three proteins form a complex, which triggers signal transduction by activating other proteins in a signaling pathway called the TGF-β pathway.
Signals transmitted by the TGF-β receptor complex trigger various responses by the cell, including the growth and division (proliferation) of cells, the maturation of cells to carry out specific functions (differentiation), cell movement (motility), and controlled cell death (apoptosis). Because TGF-β receptor type 1 helps prevent cells from growing and dividing too rapidly or in an uncontrolled way, it can suppress the formation of tumours.
Conditions referring to this gene or chromosome
Otros nombres
serine/threonine-protein kinase receptor R4
TBR-i
TBRI
TGF-beta receptor type I
TGF-beta receptor type-1
TGF-beta type I receptor
TGFR-1
TGFR1_HUMAN
transforming growth factor beta receptor I
transforming growth factor-beta receptor type I
Related patient information and medicines
Patient information leaflet
Acromegalia
Acromegalia is a rare, progressive condition in which you make too much growth hormone. This causes a range of symptoms that develop gradually, often over several years. This is because growth hormone stimulates the growth of bones, and in children, bones are still in their growing phase until the... Note : the rest of this leaflet is about.
Patient information leaflet
Cáncer de mama
These are female hormones. Overall, about 7 in 10 breast cancers are oestrogen receptor positive. Treatment can block the oestrogen in these cancers (see below). Human epidermal growth factor (HER2) es un fuentes de proteína that can affect el growth of algunas cancer cells. It is found on the surface of normal breast cells. Some breast cancer cells have a very.
Patient information leaflet
Presión arterial alta en el embarazo
Medicine to lower the blood pressure may be prescribed for a while. The most commonly used medicine is labetalol. This may allow your embarazo to progress further before delivering tu baby. The best time to induce the birth (o deliver by cesárea section) varies depending on the factors mentioned above. If you have severe pre-eclampsia, the.
Patient information leaflet
Betabloqueantes
Beta-blockers are medicines that are used to treat a variety of conditions. Their full correct name is beta-adrenoceptor blocking medicines (o beta-adrenergic blocking agents), but they are commonly just called beta-blockers. How do beta-blockers work. Beta-blockers work by blocking the transmission of certain nerve impulses. The ends of some.
Patient information leaflet
Cáncer de garganta
Throat cáncer síntomas A hoarse voice is often the first symptom because most cancers of the larynx first start on, or close by, a vocal cord. The problem is a hoarse voice is a common symptom of a viral infection of the larynx ( laryngitis ). Most people with hoarseness do not have cancer. However, laryngitis usually clears within a week or so..
Patient information leaflet
Cáncer de boca
What does cáncer de boca look like. The most common mouth cancer symptoms are a sore or ulcer in... Other treatments Newer treatments are being used in research for the treatment of mouth cancer: Targeted therapy is a type of chemotherapy that only affects or targets cancer cells: The advantage it is hoped to have over conventional chemotherapy is.
Lecturas adicionales y referencias
- transforming growth factor beta receptor 1; MedlinePlus, National Library of Medicine.
- Cardoso S, Robertson SP, Daniel PB. TGFBR1 mutations associated with Loeys-Dietz syndrome are inactivating. J Recept Signal Transduct Res. 2012 Jun;32(3):150-5. doi: 10.3109/10799893.2012.664553. Epub 2012 Mar 14.
- Goudie DR, D'Alessandro M, Merriman B, Lee H, Szeverenyi I, Avery S, O'Connor BD, Nelson SF, Coats SE, Stewart A, Christie L, Pichert G, Friedel J, Hayes I, Burrows N, Whittaker S, Gerdes AM, Broesby-Olsen S, Ferguson-Smith MA, Verma C, Lunny DP, Reversade B, Lane EB. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet. 2011 Feb 27;43(4):365-9. doi: 10.1038/ng.780.
- Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, De Backer JF, Oswald GL, Symoens S, Manouvrier S, Roberts AE, Faravelli F, Greco MA, Pyeritz RE, Milewicz DM, Coucke PJ, Cameron DE, Braverman AC, Byers PH, De Paepe AM, Dietz HC. Aneurysm syndromes caused by mutations in the TGF-beta receptor. N Engl J Med. 2006 Aug 24;355(8):788-98. doi: 10.1056/NEJMoa055695.
- Pezzini A, Del Zotto E, Giossi A, Volonghi I, Costa P, Padovani A. Transforming growth factor beta signaling perturbation in the Loeys-Dietz syndrome. Curr Med Chem. 2012;19(3):454-60. doi: 10.2174/092986712803414286.
- Van Hemelrijk C, Renard M, Loeys B. The Loeys-Dietz syndrome: an update for the clinician. Curr Opin Cardiol. 2010 Nov;25(6):546-51. doi: 10.1097/HCO.0b013e32833f0220.
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.