NLR family pyrin domain containing 1
Última actualización 8 de mayo de 2023
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El NLRP1 gene provides instructions for making a member of a family of proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins. These proteins are involved in the immune system, helping to regulate the process of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. The body then stops (inhibits) the inflammatory response to prevent damage to its own cells and tissues.
Normal function
El NLRP1 gene provides instructions for making a member of a family of proteins called nucleotide-binding domain and leucine-rich repeat containing (NLR) proteins. These proteins are involved in the immune system, helping to regulate the process of inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. The body then stops (inhibits) the inflammatory response to prevent damage to its own cells and tissues.
The NLRP1 protein is involved in the assembly of a molecular complex called an inflammasome, which helps trigger the inflammatory process in response to the presence of bacteria or viruses. Researchers believe that the NLRP1 protein may also play a role in the self-destruction of cells (apoptosis).
Conditions referring to this gene or chromosome
Otros nombres
CARD7
CLR17.1
DEFCAP
DKFZp586O1822
KIAA0926
NAC
NALP1
NALP1_HUMAN
NLR family, pyrin domain containing 1
SLEV1
VAMAS1
Related patient information and medicines
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Alergia a los frutos secos
But, if you do come into contact with nuts, and a reaction starts then treating it quickly is important. If you have a severe allergic reaction, if available, give yourself an inyección de adrenalina (epinefrina) straightaway and call an ambulance. When you come into contact with something that you are allergic to (an allergen), a group of cells in.
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Porfiria
In the porphyrias, the chemical process that is affected is the one that produces a substance called haem. Haem is mainly made in the liver and in bone marrow. Haem is used to make haemoglobin which transports oxygen around the body in red blood cells. Haem is also used to make a number of proteins in the body, needed for various important.
Patient information leaflet
Náuseas y vómitos en el embarazo
For people with hyperemesis gravidarum especially, the small risks of some types of antisickness medicine might be outweighed by the benefit they have on the physic... There are several different medicines that can be used to treat nausea and vomiting in pregnancy, including: A combination of doxylamine and pyridoxine (vitamin B6), currently sold.
Patient information leaflet
Síndrome de Cri du Chat
Cri du chat syndrome is a chromosome problem caused by a missing piece of chromosome 5. The syndrome is called cri du chat (French for cry of the cat) because affected babies often have a high-pitched cry. Not all babies with the missing piece of chromosome 5 will develop cri du chat syndrome. Cri du chat syndrome may cause a variety of.
Patient information leaflet
Anticoncepción después de tener un bebé
You will need contraception from 21 days after your baby is born. Your periods usually return about four to ten weeks after your baby's birth if you are bottle-feeding, or combining breast and bottle. If you are breastfeeding then your periods may not start until much later. For some women this might be after you have stopped breastfeeding. How.
Patient information leaflet
Alergia e intolerancia alimentaria
This can range from a mild reaction to one that is severe and life-threatening (anaphylaxis). With an allergy, even a tiny amount of the food can cause an allergic reaction to take place. Some people with a severe allergy to nuts might experience an extreme form of allergic reaction (anaphylaxis) : After eating something made in a factory that.
Lecturas adicionales y referencias
- NLR family pyrin domain containing 1; MedlinePlus, National Library of Medicine.
- Jin Y, Birlea SA, Fain PR, Spritz RA. Genetic variations in NALP1 are associated with generalized vitiligo in a Romanian population. J Invest Dermatol. 2007 Nov;127(11):2558-62. doi: 10.1038/sj.jid.5700953. Epub 2007 Jul 19.
- Jin Y, Mailloux CM, Gowan K, Riccardi SL, LaBerge G, Bennett DC, Fain PR, Spritz RA. NALP1 in vitiligo-associated multiple autoimmune disease. N Engl J Med. 2007 Mar 22;356(12):1216-25. doi: 10.1056/NEJMoa061592.
- Jin Y, Riccardi SL, Gowan K, Fain PR, Spritz RA. Fine-mapping of vitiligo susceptibility loci on chromosomes 7 and 9 and interactions with NLRP1 (NALP1). J Invest Dermatol. 2010 Mar;130(3):774-83. doi: 10.1038/jid.2009.273. Epub 2009 Sep 3.
- Pontillo A, Brandao L, Guimaraes R, Segat L, Araujo J, Crovella S. Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil. Autoimmunity. 2010 Dec;43(8):583-9. doi: 10.3109/08916930903540432. Epub 2010 Apr 7.
- Smith AG, Sturm RA. Multiple genes and locus interactions in susceptibility to vitiligo. J Invest Dermatol. 2010 Mar;130(3):643-5. doi: 10.1038/jid.2009.403.
- Spritz RA. The genetics of generalized vitiligo and associated autoimmune diseases. Pigment Cell Res. 2007 Aug;20(4):271-8. doi: 10.1111/j.1600-0749.2007.00384.x.
- Taieb A. NALP1 and the inflammasomes: challenging our perception of vitiligo and vitiligo-related autoimmune disorders. Pigment Cell Res. 2007 Aug;20(4):260-2. doi: 10.1111/j.1600-0749.2007.00393.x. No abstract available.
- Zurawek M, Fichna M, Januszkiewicz-Lewandowska D, Gryczynska M, Fichna P, Nowak J. A coding variant in NLRP1 is associated with autoimmune Addison's disease. Hum Immunol. 2010 May;71(5):530-4. doi: 10.1016/j.humimm.2010.02.004. Epub 2010 Mar 1.
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