myosin heavy chain 7
Última actualización 13 Apr 2026
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The MYH7 gene provides instructions for making a protein known as myosin-7. This protein is found in heart (cardiac) muscle and in certain skeletal muscles, which are the muscles used for movement. Specifically, myosin-7 is found in type I skeletal muscle fibers, which are also known as slow-twitch fibers. These fibers are the primary component of skeletal muscles that do not tire easily, such as the muscles involved in maintaining posture.
Normal function
The MYH7 gene provides instructions for making a protein known as myosin-7. This protein is found in heart (cardiac) muscle and in certain skeletal muscles, which are the muscles used for movement. Specifically, myosin-7 is found in type I skeletal muscle fibers, which are also known as slow-twitch fibers. These fibers are the primary component of skeletal muscles that do not tire easily, such as the muscles involved in maintaining posture.
Myosin-7 helps generate the mechanical force that is needed for muscles to contract. It combines with other proteins to form the thick filaments that are found within structures called sarcomeres. Sarcomeres are the basic units of muscle contraction; they are composed of overlapping thick filaments and thin filaments. These thick and thin filaments undergo cycles of attachment and release, which allow the thin filaments to slide past the thick filaments. These movements shorten the sarcomere, which causes the muscle to contract. Regular contractions of cardiac muscle pump blood to the rest of the body, while the coordinated contraction and relaxation of skeletal muscles allow the body to move.
Conditions referring to this gene or chromosome
Otros nombres
CMD1S
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Lecturas adicionales y referencias
- myosin heavy chain 7; MedlinePlus, National Library of Medicine.
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- Viswanathan MC, Tham RC, Kronert WA, Sarsoza F, Trujillo AS, Cammarato A, Bernstein SI. Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo. Hum Mol Genet. 2017 Dec 15;26(24):4799-4813. doi: 10.1093/hmg/ddx359.
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