Can I take Metformin and Sertraline together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking sertraline alongside metformin may occasionally affect your blood sugar levels. Some patients find their blood sugar drops lower than usual (hypoglycaemia), while others may see a slight increase. Additionally, both medications can cause stomach-related side effects like nausea or diarrhoea, which might be more noticeable when taken together.
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Why this happens
Sertraline belongs to a group of medicines called SSRIs, which can change how the body handles glucose and may increase the body's sensitivity to insulin. While the exact way they interact with metformin isn't fully understood, it is known that starting or stopping an antidepressant can cause fluctuations in blood sugar control.
What you should do
You can take these medicines together, but you should monitor your blood sugar levels more closely when you first start sertraline or if your dose changes. If you notice signs of low blood sugar (such as feeling shaky, sweaty, hungry, or confused), treat it as usual and inform your doctor. Do not change your metformin dose without medical advice.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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