Can I take Promethazine and Vitamin d3 together?
Drug interaction guide
Originally published 25 Jan 2026
Satisface las necesidades del paciente directrices editoriales
- DescargarDescargar
- Compartir
- Idioma
- Debate
There are no known significant interactions between promethazine and vitamin D3 (cholecalciferol). It is generally considered safe to take these two medications together.
En este artículo:
Seguir leyendo
Why this happens
Promethazine is an antihistamine processed primarily by the liver's cytochrome P450 enzymes, while vitamin D3 is a fat-soluble vitamin that undergoes a different metabolic pathway (hydroxylation in the liver and kidneys). They do not interfere with each other's absorption, metabolism, or effects in the body.
What you should do
You can continue to take both medications as prescribed. As with any supplement, it is best to take vitamin D3 with a meal containing some fat to help with absorption. Promethazine can cause drowsiness, so be aware of how it affects you before driving or operating machinery.
Seguir leyendo
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Tratamiento y medicación
Can I take Bisoprolol and Trimbow pmdi // pressurised inhalation together?
Bisoprolol and Trimbow (which contains formoterol) work in opposite ways on the airways. Bisoprolol may cause the airways to narrow, making it harder to breathe and potentially triggering asthma or COPD symptoms. It also makes the formoterol in the Trimbow inhaler less effective at opening your airways.

Tratamiento y medicación
Can I take Ashwagandha and Oestrogel pump-pack /actuation together?
Ashwagandha may increase the levels of oestrogen in your body, potentially making the effects of your Oestrogel stronger than intended. It might also interfere with how your body naturally balances hormones.
Seguir leyendo
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

Pregunte, comparta, conecte.
Explore debates, formule preguntas y comparta experiencias sobre cientos de temas de salud.

¿Se encuentra mal?
Evalúe sus síntomas en línea de forma gratuita
Suscríbase al boletín informativo para pacientes.
Tu dosis semanal de consejos de salud claros y fiables, redactados para ayudarte a sentirte informado, seguro y en control.
Al suscribirte, aceptas nuestra Política de privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.