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Can I take Co-amoxiclav and Ramipril together?

Guía de interacción de medicamentos

Taking co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection.

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Por qué sucede esto

Both drugs can affect how the kidneys work and how the body handles potassium. Additionally, certain types of antibiotics (like co-amoxiclav) may rarely increase the risk of swelling reactions when taken with ACE inhibitors like ramipril.

It is generally safe to take these together, but you should be aware of the signs of an allergic reaction. Seek immediate medical help if you experience swelling of the face, lips, or tongue, or have difficulty breathing. Your doctor may want to check your kidney function or potassium levels with a blood test if you are taking these for a long period or if you are feeling very unwell.

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Embarazo

You must not take ramipril if you are pregnant. It can cause serious harm to your unborn baby, particularly affecting their kidney development.

Penicillin allergy

Do not take co-amoxiclav if you have ever had a severe allergic reaction (such as a skin rash, swelling of the face or neck, or difficulty breathing) to penicillin or any other antibiotic.

Angioedema (swelling)

Seek immediate medical help if you experience swelling of the face, lips, tongue, or throat. Ramipril can cause a rare but life-threatening allergic reaction called angioedema.

Problemas del hígado

Seek immediate medical advice if you develop yellowing of the eyes or skin (jaundice) or pale stools, as co-amoxiclav can cause serious liver inflammation, sometimes weeks after finishing the course.

Alcohol

While alcohol does not directly interact with co-amoxiclav, it is generally advised to avoid alcohol while you are unwell with an infection, as it can make you feel more tired and may contribute to dehydration. Drinking alcohol while taking ramipril can increase the blood pressure-lowering effect of the medicine, which may make you feel dizzy, lightheaded, or faint. It is best to keep alcohol intake to a minimum, especially when you first start taking ramipril or when your dose is increased.

Salt substitutes (Potassium-rich)

Ramipril can increase the levels of potassium in your blood. You should avoid using salt substitutes that contain potassium (such as Lo-Salt) while taking this medicine, as this could lead to dangerously high potassium levels.

Alimentos (General)

To reduce the risk of stomach upset or indigestion, it is best to take co-amoxiclav at the start of a meal or with a snack.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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