Can I take Pregabalin and Tizanidine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking pregabalin and tizanidine together can significantly increase the risk of side effects such as extreme drowsiness, dizziness, and confusion. You may find it very difficult to concentrate or stay awake. There is also an increased risk of physical coordination problems, which can lead to falls, and a risk of slowed or shallow breathing.
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Why this happens
Both medicines act as central nervous system (CNS) depressants. While they work in different ways, they both slow down brain activity. When taken together, their effects add up (a 'synergistic' effect), making the sedative impact much stronger than if either were taken alone.
What you should do
Use this combination with caution and only under strict medical supervision. Do not drive, operate heavy machinery, or perform dangerous tasks until you know how this combination affects you. Avoid alcohol, as it will make these side effects much worse. If you experience extreme sleepiness or difficulty breathing, seek medical help immediately. Your doctor may need to adjust your doses.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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