Can I take Venlafaxine and Wellbutrin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking venlafaxine and bupropion (Wellbutrin) together can increase the risk of having a seizure. It may also lead to a rare but serious condition called serotonin syndrome, which can cause symptoms like shivering, sweating, confusion, and a fast heartbeat. Additionally, bupropion can cause venlafaxine levels to build up in your body, potentially increasing side effects like dizziness, dry mouth, or nausea.
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Why this happens
Bupropion can lower the 'seizure threshold', making seizures more likely, especially when combined with other antidepressants like venlafaxine. Furthermore, bupropion blocks a specific liver enzyme (CYP2D6) that your body uses to break down venlafaxine. This causes venlafaxine levels to rise. Both drugs also affect brain chemicals, which can occasionally lead to too much serotonin (serotonin syndrome).
What you should do
You should only take these two medications together if they have been specifically prescribed by a specialist who is monitoring you closely. If you have a history of seizures, head injury, or eating disorders, make sure your doctor knows. Seek immediate medical help if you experience a seizure, extreme agitation, hallucinations, or a very high fever.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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