Can I take Allopurinol and Co-amoxiclav together?

It is generally considered safe to take allopurinol y co-amoxiclav together, but caution is advised as taking them together increases the risk of developing a rash.

If you notice any new skin rash, redness, or itching, contact your doctor immediately. If you develop a rash along with a fever or swelling of the face, seek urgent medical help.

Por qué sucede esto

The exact reason isn't fully understood, but allopurinol seems to make the immune system more sensitive to penicillin-type antibiotics like co-amoxiclav. This makes an allergic-style skin reaction more likely to happen.

You may be experiencing an interaction between allopurinol and co-amoxiclav if:

• You develop skin rashes, itching, or hives.

• You experience fever, chills, or flu-like symptoms.

• You notice unusual bruising or bleeding.

• You feel tired, weak, or generally unwell.

• You have swelling of the face, lips, or throat, which may indicate an allergic reaction.

• Los síntomas aparecen poco después de comenzar o aumentar la dosis de cualquiera de los medicamentos.

Si tienes alguno de los síntomas mencionados, deberías:

• Stop taking the medicines and seek advice from your GP or pharmacist immediately.

• Seek urgent medical help if you develop swelling of the face, lips, or throat, or have difficulty breathing.

• Do not restart the medicines until a healthcare professional confirms it is safe.

• Informe a su profesional de la salud sobre todos los demás medicamentos y suplementos que está tomando.

• Attend any blood tests or monitoring recommended to check for allergic reactions or other side effects.

Severe skin rash

Stop taking allopurinol immediately and seek urgent medical advice if you develop a skin rash, peeling skin, or sores on your lips or mouth. This can be a sign of a rare but life-threatening allergic reaction.

Penicillin allergy

Do not take co-amoxiclav if you have ever had a severe allergic reaction (such as anafilaxia or a skin rash) to penicillin or any other 'beta-lactam' antibiotic, as this can be fatal.

Liver problems (jaundice)

Seek medical advice if you develop yellowing of the skin or eyes (jaundice) or dark pee (urine). Co-amoxiclav can cause liver inflammation, which may sometimes occur even after you have finished the course.

Alcohol

Alcohol can increase the levels of uric acid in your blood, which makes allopurinol less effective at preventing gout attacks. It is best to limit or avoid alcohol, especially beer and spirits.

Cafeína

High intake of caffeine may interfere with how allopurinol works to lower uric acid. Try to maintain a consistent, moderate intake rather than consuming very large amounts.

Water/fluids

While not a negative interaction, it is vital to drink plenty of fluids (2 to 3 litres a day) while taking allopurinol to help prevent kidney stones.

Food (general)

To reduce the chance of feeling sick or having stomach upset, it is recommended to take co-amoxiclav at the start of a meal.

Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.