Can I take Candesartan and Eplerenone together?
Guía de interacción de medicamentos
Publicado originalmente 25 Ene 2026
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Taking these two medicines together can significantly increase the level of potassium in your blood (a condition called hyperkalaemia). While both drugs are used to treat heart conditions or high blood pressure, having too much potassium can be dangerous and may lead to serious heart rhythm problems.
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Por qué sucede esto
Both candesartan and eplerenone work by affecting a hormone system in the body that regulates salt and water balance. Specifically, they both cause the kidneys to keep hold of potassium rather than flushing it out in the urine. When used together, this 'potassium-sparing' effect is doubled.
Lo que deberías hacer
Volver al contenidoYou must speak to your doctor before taking these together. If prescribed both, your doctor will need to monitor your kidney function and potassium levels very closely with regular blood tests. Seek medical help immediately if you experience muscle weakness, tingling sensations, or an irregular heartbeat. Avoid using salt substitutes containing potassium (such as Lo-Salt) while taking these medicines.
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Precauciones importantes
Volver al contenidoEmbarazo
You must not take these medicines if you are pregnant or planning to become pregnant. They can cause serious harm or death to an unborn baby, particularly if used during the second and third trimesters.
Niveles altos de potasio (Hiperpotasemia)
Both medicines increase potassium levels in your blood. You must avoid using potassium supplements or salt substitutes containing potassium, as dangerously high levels can cause life-threatening heart rhythm problems.
Kidney function and NSAID use
Taking anti-inflammatory painkillers (like ibuprofen or naproxen) while on these medicines can significantly increase the risk of sudden kidney failure. Check with a pharmacist before using any over-the-counter pain relief.
Advertencias sobre alimentos y bebidas
Volver al contenidoAlcohol
Drinking alcohol while taking these medicines can cause your blood pressure to drop too low. This may make you feel dizzy, lightheaded, or faint, especially when standing up. It is best to keep your alcohol intake within recommended limits and see how the medicine affects you first.
Jugo de toronja
You should avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can increase the level of eplerenone in your blood, which may increase the risk of side effects.
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Uso de otros medicamentos
Volver al contenidoTaking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
25 Ene 2026 | Publicado originalmente

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