Wnt family member 10A
Última actualización 18 Aug 2020
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
El WNT10A gene is part of a large family of WNT genes, which play critical roles in development starting before birth. These genes provide instructions for making proteins that participate in chemical signaling pathways in the body. Wnt signaling controls the activity of certain genes and regulates the interactions between cells during embryonic development.
Normal function
El WNT10A gene is part of a large family of WNT genes, which play critical roles in development starting before birth. These genes provide instructions for making proteins that participate in chemical signaling pathways in the body. Wnt signaling controls the activity of certain genes and regulates the interactions between cells during embryonic development.
The protein produced from the WNT10A gene plays a role in the development of many parts of the body. It appears to be essential for the formation of tissues that arise from an embryonic cell layer called the ectoderm. These tissues include the skin, hair, nails, teeth, and sweat glands. Researchers believe that the WNT10A protein is particularly important for the formation and shaping of both baby (primary) teeth and adult (permanent) teeth.
Conditions referring to this gene or chromosome
Otros nombres
OODD
protein Wnt-10a precursor
STHAG4
wingless-type MMTV integration site family, member 10A
Related patient information and medicines
Patient information leaflet
Enfermedad de Huntington
La enfermedad de Huntington es causada por un gen defectuoso que heredas de tus padres. Enfermedad de Huntington es an autosomal dominant condition, meaning you can inherit the disease from just one of your parents. ...of the gene, there is a 50:50 chance that each child they have will inherit the faulty geneIf a member of your family who is carrying.
Patient information leaflet
Enfermedad renal poliquística
Autosomal recessive polycystic kidney disease (ARPKD) This is a rare condition which affects about 1 in 20,000 people. Problems typically develop soon after birth. Non-hereditary polycystic kidney disease In about 1 in 10 people who develop polycystic kidney disease, the faulty gene is a new mutation in the affected person. Although people with.
Patient information leaflet
Retinoblastoma
Retinoblastoma es an uncommon cancer of the eye which occurs in children under the age of 5. This leaflet describes retinoblastoma. It discusses the symptoms and signs of retinoblastoma and the management options children with retinoblastoma may be offered. Siblings of an affected child in a family in which no other family members have ha... See.
Patient information leaflet
Trastorno por consumo de alcohol
Many people drink alcohol. For some, alcohol is something that... What is alcohol use disorder. Trastorno por consumo de alcohol means drinking alcohol in a way that causes harm. If you or a family member tiene alcohol use disorder then treatment and support can be provided to help you or your family member reduce or stop drinking alcohol. Alcohol use disorder.
Patient information leaflet
Distrofia muscular de Duchenne
The name Duchenne comes from the doctor who first studied this condition. How common is Duchenne muscular dystrophy. About 1 in 3,500 boys in the UK are born with DMD. There are other types of muscular dystrophy too, which are rarer. Therefore, boys with the DMD gene always have symptoms of the disease. The DMD gene can be passed on from parent to.
Patient information leaflet
Esquizofrenia
Is schizophrenia genetic. Inherited (genetic) factors are thought to be important. For example, a close family member (child, brother, sister, parent) of someone with schizophrenia has a 1 in 10 chance of also developing the condition. This is 10 times the normal chance. A child born to a mother and father who both have schizophrenia has a higher.
Lecturas adicionales y referencias
- Wnt family member 10A; MedlinePlus, National Library of Medicine.
- Adaimy L, Chouery E, Megarbane H, Mroueh S, Delague V, Nicolas E, Belguith H, de Mazancourt P, Megarbane A. Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia. Am J Hum Genet. 2007 Oct;81(4):821-8. doi: 10.1086/520064. Epub 2007 Aug 9.
- Arzoo PS, Klar J, Bergendal B, Norderyd J, Dahl N. WNT10A mutations account for (1/4) of population-based isolated oligodontia and show phenotypic correlations. Am J Med Genet A. 2014 Feb;164A(2):353-9. doi: 10.1002/ajmg.a.36243. Epub 2013 Nov 25.
- Bohring A, Stamm T, Spaich C, Haase C, Spree K, Hehr U, Hoffmann M, Ledig S, Sel S, Wieacker P, Ropke A. WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes. Am J Hum Genet. 2009 Jul;85(1):97-105. doi: 10.1016/j.ajhg.2009.06.001. Epub 2009 Jun 25.
- Cluzeau C, Hadj-Rabia S, Jambou M, Mansour S, Guigue P, Masmoudi S, Bal E, Chassaing N, Vincent MC, Viot G, Clauss F, Maniere MC, Toupenay S, Le Merrer M, Lyonnet S, Cormier-Daire V, Amiel J, Faivre L, de Prost Y, Munnich A, Bonnefont JP, Bodemer C, Smahi A. Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. Hum Mutat. 2011 Jan;32(1):70-2. doi: 10.1002/humu.21384.
- Kantaputra P, Kaewgahya M, Jotikasthira D, Kantaputra W. Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations. Am J Med Genet A. 2014 Apr;164A(4):1041-8. doi: 10.1002/ajmg.a.36388. Epub 2014 Jan 23.
- Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct;164A(10):2455-60. doi: 10.1002/ajmg.a.36520. Epub 2014 Apr 3.
- Plaisancie J, Bailleul-Forestier I, Gaston V, Vaysse F, Lacombe D, Holder-Espinasse M, Abramowicz M, Coubes C, Plessis G, Faivre L, Demeer B, Vincent-Delorme C, Dollfus H, Sigaudy S, Guillen-Navarro E, Verloes A, Jonveaux P, Martin-Coignard D, Colin E, Bieth E, Calvas P, Chassaing N. Mutations in WNT10A are frequently involved in oligodontia associated with minor signs of ectodermal dysplasia. Am J Med Genet A. 2013 Apr;161A(4):671-8. doi: 10.1002/ajmg.a.35747. Epub 2013 Feb 7.
- Tardieu C, Jung S, Niederreither K, Prasad M, Hadj-Rabia S, Philip N, Mallet A, Consolino E, Sfeir E, Noueiri B, Chassaing N, Dollfus H, Maniere MC, Bloch-Zupan A, Clauss F. Dental and extra-oral clinical features in 41 patients with WNT10A gene mutations: A multicentric genotype-phenotype study. Clin Genet. 2017 Nov;92(5):477-486. doi: 10.1111/cge.12972. Epub 2017 Mar 19.
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.