TGFB induced factor homeobox 1
Última actualización 18 Aug 2020
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
El TGIF1 gene provides instructions for making a protein called TG-interacting factor. This protein is important for normal development of the front part of the brain (forebrain). TG-interacting factor is a transcription factor, which means that it regulates the activity of certain genes. This protein turns off genes by attaching (binding) to specific regions of DNA or by interacting with other DNA-binding proteins.
Normal function
El TGIF1 gene provides instructions for making a protein called TG-interacting factor. This protein is important for normal development of the front part of the brain (forebrain). TG-interacting factor is a transcription factor, which means that it regulates the activity of certain genes. This protein turns off genes by attaching (binding) to specific regions of DNA or by interacting with other DNA-binding proteins.
TG-interacting factor regulates signaling pathways that are important for embryonic development. This protein blocks the signals of the transforming growth factor beta (TGF-β) pathway. This signaling pathway transmits chemical signals from the cell surface to the nucleus, which allows the environment outside the cell to affect how the cell produces other proteins. TG-interacting factor also blocks a molecule called retinoic acid from regulating gene activity. Retinoic acid, a form of vitamin A, binds to a group of transcription factors that regulate a number of genes important for early development. By blocking these signaling pathways, TG-interacting factor ensures that certain genes are turned off at the proper time.
Conditions referring to this gene or chromosome
Otros nombres
5'-TG-3' interacting factor
5'-TG-3'-interacting factor 1
homeobox protein TGIF
homeobox protein TGIF1
HPE4
MGC39747
MGC5066
TALE homeobox TG-interacting factor
TGFB-induced factor homeobox 1
TGIF
TGIF1_HUMAN
transforming growth factor-beta-induced factor
Related patient information and medicines
Patient information leaflet
Fibrosis pulmonar
Fibrosis pulmonar is a serious lung enfermedad where the tiny air sacs of the lungs (the alveoli) and the lung tissue next to the alveoli become damaged and scarred, resulting in lung fibrosis. The main symptom is shortness of breath that gradually gets worse. The cause is often not known but pulmonary fibrosis can be caused by a variety of.
Patient information leaflet
Muestreo de vellosidades coriónicas
A note about DNA, genes and chromosomes In most cells of your body you have 46 chromosomes arranged in 23 pairs. 22 of the pairs are matching pairs. The 23rd pair is the sex chromosomes, which match exactly in women (who have two X chromosomes) but not in men (who have one X and one Y). One chromosome from each pair comes from your mother and one.
Patient information leaflet
Trombofilia
The body has a natural clotting process in the blood, which is altered in thrombophilia. The normal clotting process is called haemostasis. Thrombophilia refers to a group of conditions where the blood clots more easily than normal. This can lead to unwanted blood clots (called thromboses) forming within blood vessels. These blood clots can cause.
Patient information leaflet
Diabetes tipo 1
Diabetes tipo 1 is the type de diabetes that typically develops in children and in young adults. In type 1 diabetes the body stops making insulin and the blood sugar (glucose) level goes very high. Treatment to control the blood glucose level is with insulin injections and a healthy diet. They include reducing blood pressure if it is high and.
Patient information leaflet
Espondilitis anquilosante
The type of inflammation in AS causes the affected joints to join together, therefore reducing mobility. Espondilitis anquilosante es an auto-immune disease. It is not known exactly why ankylosing spondylitis occurs but there is a genetic predisposition. 6 out of 100 people who have a particular gene variant called HLA-B27 have ankylosing spondylitis.
Patient information leaflet
Síndrome antifosfolípido
Síndrome antifosfolípido (APS) - also called Hughes' syndrome - makes blood more likely than normal to clot (a thrombophilia ). This increases the risk of developing blood clots (called thromboses) within blood vessels. APS can cause disability, serious illness and even death in a pregnant woman or her unborn baby if untreated. Unfortunately, it.
Lecturas adicionales y referencias
- TGFB induced factor homeobox 1; MedlinePlus, National Library of Medicine.
- Aguilella C, Dubourg C, Attia-Sobol J, Vigneron J, Blayau M, Pasquier L, Lazaro L, Odent S, David V. Molecular screening of the TGIF gene in holoprosencephaly: identification of two novel mutations. Hum Genet. 2003 Feb;112(2):131-4. doi: 10.1007/s00439-002-0862-8. Epub 2002 Nov 21.
- Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V. Holoprosencephaly. Orphanet J Rare Dis. 2007 Feb 2;2:8. doi: 10.1186/1750-1172-2-8.
- El-Jaick KB, Powers SE, Bartholin L, Myers KR, Hahn J, Orioli IM, Ouspenskaia M, Lacbawan F, Roessler E, Wotton D, Muenke M. Functional analysis of mutations in TGIF associated with holoprosencephaly. Mol Genet Metab. 2007 Jan;90(1):97-111. doi: 10.1016/j.ymgme.2006.07.011. Epub 2006 Sep 7.
- Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massague J, Muenke M, Elledge SJ. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat Genet. 2000 Jun;25(2):205-8. doi: 10.1038/76074.
- Roessler E, Muenke M. The molecular genetics of holoprosencephaly. Am J Med Genet C Semin Med Genet. 2010 Feb 15;154C(1):52-61. doi: 10.1002/ajmg.c.30236.
- Solomon BD, Mercier S, Velez JI, Pineda-Alvarez DE, Wyllie A, Zhou N, Dubourg C, David V, Odent S, Roessler E, Muenke M. Analysis of genotype-phenotype correlations in human holoprosencephaly. Am J Med Genet C Semin Med Genet. 2010 Feb 15;154C(1):133-41. doi: 10.1002/ajmg.c.30240.
- Tekendo-Ngongang C, Muenke M, Kruszka P. Holoprosencephaly Overview. 2000 Dec 27 [updated 2026 Jun 9]. In: Adam MP, Bick S, Mirzaa GM, Wallace SE, Amemiya A, editors. GeneReviews(R) [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2026. Available from http://www.ncbi.nlm.nih.gov/books/NBK1530/
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.