synuclein alpha
Última actualización 17 Jul 2023
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
El SNCA gene provides instructions for making a small protein called alpha-synuclein. Alpha-synuclein is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function.
Normal function
El SNCA gene provides instructions for making a small protein called alpha-synuclein. Alpha-synuclein is abundant in the brain, and smaller amounts are found in the heart, muscles, and other tissues. In the brain, alpha-synuclein is found mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function.
Although the function of alpha-synuclein is not well understood, studies suggest that it plays an important role in maintaining an adequate supply of synaptic vesicles in presynaptic terminals. It may also help regulate the release of dopamine, a neurotransmitter that is critical for controlling the start and stop of voluntary and involuntary movements. Alpha-synuclein may also play a role in the movement of structures called microtubules that help cells maintain their shape.
Conditions referring to this gene or chromosome
Otros nombres
alpha-synuclein
NACP
nonA-beta component of AD amyloid
PARK1
PARK4
PD1
synuclein, alpha (non A4 component of amyloid precursor)
SYUA_HUMAN
Related patient information and medicines
Patient information leaflet
enfermedad de Parkinson
Research into Parkinson's disease Research into PD is active. For example, one main aim of research is to find medicines that prevent the damage to the affected cells, rather than just treating the symptoms, which is t... Research is underway using stem cell therapy to help treat PD. Other researchers are looking at alpha synuclein, a protein that.
Patient information leaflet
¿Puedo tomar Rivaroxaban y Tamsulosina juntos?
However, both medicines can occasionally cause dizziness or lightheadedness,... Taking them together might slightly increase the chance of feeling faint. Why this happens Rivaroxaban es an anticoagulant (blood thinner) and tamsulosin is an alpha-blocker used for prostate symptoms. They are processed by different pathways in the liver and do not.
Patient information leaflet
Uveítis
The doctor may start. This allows them to assess any differences in vision between your eyes. What are the complications of uveitis. Complications that can sometimes occur with uveitis include: Formation of synechiae : the name 'synechiae' is given to the 'bands' de tissue that can form between the iris and the lens due to inflammation. Eye drops.
Patient information leaflet
¿Puedo tomar Lansoprazol y Tamsulosina juntos?
There are no known significant interactions between... It is generally considered safe to take these two medicines together. Why this happens Lansoprazole is a proton pump inhibitor (PPI) used to reduce stomach acid, and tamsulosin is an alpha-blocker used to help with urinary symptoms. They are processed by different pathways in the liver and do.
Patient information leaflet
Sangre en el semen
Hemospermia means there is blood in el semen. Usually there are no other symptoms such as pain. The haematospermia itself does not need any treatment. Medicines If you have persistent haematospermia without an identified cause then a type of medicine called a 5-alpha reductase inhibitor como finasterida o dutasterida may be effective..
Patient information leaflet
Insuficiencia hepática
These include paracetamol poisoning, infections (for example, hepatitis B or hepatitis C), acute fatty liver of pregna. For some people with liver failure the cause is not known. What are the functions of the liver. A healthy liver does a number of essential functions for the body. These include: Removing harmful substances from the body,.
Lecturas adicionales y referencias
- synuclein alpha; MedlinePlus, National Library of Medicine.
- Bonini NM, Giasson BI. Snaring the function of alpha-synuclein. Cell. 2005 Nov 4;123(3):359-61. doi: 10.1016/j.cell.2005.10.017.
- Federoff M, Schottlaender LV, Houlden H, Singleton A. Multiple system atrophy: the application of genetics in understanding etiology. Clin Auton Res. 2015 Feb;25(1):19-36. doi: 10.1007/s10286-014-0267-5. Epub 2015 Feb 17.
- Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Curr Top Dev Biol. 2004;60:17-54. doi: 10.1016/S0070-2153(04)60002-0.
- Nuytemans K, Theuns J, Cruts M, Van Broeckhoven C. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat. 2010 Jul;31(7):763-80. doi: 10.1002/humu.21277.
- Puschmann A, Bhidayasiri R, Weiner WJ. Synucleinopathies from bench to bedside. Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S24-7. doi: 10.1016/S1353-8020(11)70010-4.
- Rosborough K, Patel N, Kalia LV. alpha-Synuclein and Parkinsonism: Updates and Future Perspectives. Curr Neurol Neurosci Rep. 2017 Apr;17(4):31. doi: 10.1007/s11910-017-0737-y.
- Scholz SW, Houlden H, Schulte C, Sharma M, Li A, Berg D, Melchers A, Paudel R, Gibbs JR, Simon-Sanchez J, Paisan-Ruiz C, Bras J, Ding J, Chen H, Traynor BJ, Arepalli S, Zonozi RR, Revesz T, Holton J, Wood N, Lees A, Oertel W, Wullner U, Goldwurm S, Pellecchia MT, Illig T, Riess O, Fernandez HH, Rodriguez RL, Okun MS, Poewe W, Wenning GK, Hardy JA, Singleton AB, Del Sorbo F, Schneider S, Bhatia KP, Gasser T. SNCA variants are associated with increased risk for multiple system atrophy. Ann Neurol. 2009 May;65(5):610-4. doi: 10.1002/ana.21685.
- Sidhu A, Wersinger C, Vernier P. alpha-Synuclein regulation of the dopaminergic transporter: a possible role in the pathogenesis of Parkinson's disease. FEBS Lett. 2004 May 7;565(1-3):1-5. doi: 10.1016/j.febslet.2004.03.063.
- Vekrellis K, Xilouri M, Emmanouilidou E, Rideout HJ, Stefanis L. Pathological roles of alpha-synuclein in neurological disorders. Lancet Neurol. 2011 Nov;10(11):1015-25. doi: 10.1016/S1474-4422(11)70213-7.
- Yun JY, Lee WW, Lee JY, Kim HJ, Park SS, Jeon BS. SNCA variants and multiple system atrophy. Ann Neurol. 2010 Apr;67(4):554-5. doi: 10.1002/ana.21889. No abstract available.
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.