regulatory factor X5
Última actualización 18 Aug 2020
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
El RFX5 gene provides instructions for making a protein that primarily helps control the activity (transcription) of genes called major histocompatibility complex (MHC) class II genes. Transcription is the first step in the production of proteins, and RFX5 is critical for the production of specialized immune proteins called MHC class II proteins from these genes.
Normal function
El RFX5 gene provides instructions for making a protein that primarily helps control the activity (transcription) of genes called major histocompatibility complex (MHC) class II genes. Transcription is the first step in the production of proteins, and RFX5 is critical for the production of specialized immune proteins called MHC class II proteins from these genes.
The RFX5 protein is part of a group of proteins called the regulatory factor X (RFX) complex. This complex attaches to a specific region of DNA involved in the regulation of MHC class II gene activity. The RFX5 protein helps the complex attach to the correct region of DNA. The RFX complex attracts other necessary proteins to this region and helps turn on MHC class II gene transcription, allowing production of MHC class II proteins.
MHC class II proteins are found on the surface of several types of immune cells, including white blood cells (lymphocytes) that are involved in immune reactions. These proteins play an important role in the body's immune response to foreign invaders, such as bacteria, viruses, and fungi. To help the body recognise and fight infections, MHC class II proteins bind to fragments of proteins (peptides) from foreign invaders so that other specialized immune system cells can interact with them. When these immune system cells recognise the peptides as harmful, they trigger the lymphocytes and other immune cells to launch immune responses to get rid of the foreign invaders.
The RFX complex also appears to play a role in the transcription of MHC class I genes, which provide instructions for making immune system proteins called MHC class I proteins. Like MHC class II proteins, MHC class I proteins attach to peptides from foreign invaders and present them to specific immune system cells. These cells then attack the foreign invaders to rid them from the body. While the RFX complex is able to help control MHC class I gene activity, it is not the primary regulator of these genes. Other proteins play a more prominent role in their transcription.
Conditions referring to this gene or chromosome
Otros nombres
DNA-binding protein RFX5
regulatory factor X 5
regulatory factor X, 5 (influences HLA class II expression)
Related patient information and medicines
Patient information leaflet
Negligencia médica
There is a separate Health Service Ombudsman for England, Scotland, Wales and Northern Ireland. Governing bodies for health professionals Healthcare professionals son regulated por governing bodies, which have the power to prevent them from practising if they are unfit to do so. (In Northern Ireland, pharmacists are regulated by the Pharmaceutical.
Patient information leaflet
Medicamentos para la epilepsia y efectos secundarios
Therefore, in January 2024, the Medicines and Healthcare products Regulatory Agency recommended that: Valproate must not be started in new patients (male or female) younger than 55 years, unless two specialists independently consider and document that there is no other effective or tolerated treatment, or there are compelling reasons that the.
Patient information leaflet
Probióticos y prebióticos
There are some concerns that probiotics... The quality of probiotics depends on the manufacturer and, since most are not manufactured as medicines, they do not have to satisfy the much stricter criterios for the regulatory standards of medicines. There are concerns regarding many commercially available products - a review showed several problems:.
Patient information leaflet
¿Puedo tomar Apixaban y Rybelsus juntos?
There ... These two medicines work in different ways and do not typically interfere with how the other is absorbed, broken down, or removed from the body. Why this happens Apixaban es an anticoagulant (blood thinner) that works by blocking a clotting factor called Factor Xa. Rybelsus is a GLP-1 receptor agonist used for type 2 diabetes that mimics.
Patient information leaflet
Medicina complementaria y alternativa
Complementary and alternative medicine (CAM) es used by many people. Regulation: Osteopathy es regulated by the General Osteopathic Council. Quiropráctica es regulated by the General Chiropractic Council. Regulation: El Medicamentos y Salud products Regulatory Agency (MHRA) is the government agency which is responsible for ensuring that.
Patient information leaflet
¿Puedo tomar Apixabán y Bisoprolol juntos?
There is no direct interaction between apixaban and bisoprolol. They work in different ways and do not interfere with how the body processes each other. Why this happens Apixaban is an anticoagulant (blood thinner) that works by blocking a clotting factor called Factor Xa. Bisoprolol is a beta-blocker that slows the heart rate and lowers blood.
Lecturas adicionales y referencias
- regulatory factor X5; MedlinePlus, National Library of Medicine.
- Burd AL, Ingraham RH, Goldrick SE, Kroe RR, Crute JJ, Grygon CA. Assembly of major histocompatibility complex (MHC) class II transcription factors: association and promoter recognition of RFX proteins. Biochemistry. 2004 Oct 12;43(40):12750-60. doi: 10.1021/bi030262o.
- Garvie CW, Boss JM. Assembly of the RFX complex on the MHCII promoter: role of RFXAP and RFXB in relieving autoinhibition of RFX5. Biochim Biophys Acta. 2008 Dec;1779(12):797-804. doi: 10.1016/j.bbagrm.2008.07.012. Epub 2008 Aug 6.
- Gobin SJ, Peijnenburg A, van Eggermond M, van Zutphen M, van den Berg R, van den Elsen PJ. The RFX complex is crucial for the constitutive and CIITA-mediated transactivation of MHC class I and beta2-microglobulin genes. Immunity. 1998 Oct;9(4):531-41. doi: 10.1016/s1074-7613(00)80636-6.
- Villard J, Reith W, Barras E, Gos A, Morris MA, Antonarakis SE, Van den Elsen PJ, Mach B. Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency. Hum Mutat. 1997;10(6):430-5. doi: 10.1002/(SICI)1098-1004(1997)10:63.0.CO;2-H.
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.