protein tyrosine phosphatase non-receptor type 22
Última actualización 8 Sept 2025
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
- Agregar a fuentes preferidas en Google
El PTPN22 gene provides instructions for making a protein that belongs to the PTP (protein tyrosine phosphatases) family. PTP proteins play a role in regulating a process called signal transduction. In signal transduction, the protein relays signals from outside the cell to the cell nucleus. These signals instruct the cell to grow and divide or to mature and take on specialized functions.
Normal function
El PTPN22 gene provides instructions for making a protein that belongs to the PTP (protein tyrosine phosphatases) family. PTP proteins play a role in regulating a process called signal transduction. In signal transduction, the protein relays signals from outside the cell to the cell nucleus. These signals instruct the cell to grow and divide or to mature and take on specialized functions.
The PTPN22 protein is involved in signaling that helps control the activity of immune system cells called T cells. T cells identify foreign substances and defend the body against infection.
Conditions referring to this gene or chromosome
Otros nombres
lymphoid phosphatase
lymphoid-specific protein tyrosine phosphatase
LYP
LYP1
LYP2
PEP
PEST-domain phosphatase
protein tyrosine phosphatase, non-receptor type 8
PTN22_HUMAN
PTPN8
tyrosine-protein phosphatase non-receptor type 22
Related patient information and medicines
Patient information leaflet
Enfermedad renal diabética
Enfermedad renal diabética (diabetic nephropathy) is a complication that occurs in some people with diabetes. Diabetic kidney disease is one of the causes of chronic kidney disease , a long-term condition where the kidneys do not work as well as they should. In diabetic kidney disease, the filters of the kidneys, the glomeruli, become damaged..
Patient information leaflet
Cáncer de mama
Most develop in women over the age of 50 pero younger women are sometimes affected. Breast cancer develops from a cancerous (malignant) cell which develops in the lining of a duct or lobule in one of the breasts. Breast cancer can also develop in men, although this is much less common than breast cancer in women. Anatomy of the breasts Breast.
Patient information leaflet
Pruebas de función hepática
Pruebas de función hepática are a set of sangre tests commonly done to check on the health of your liver. Changes in liver function tests give a clue as to whether your liver is under strain, inflamed, infected or diseased, and how badly. The pattern of the liver function tests can give a clue to the cause and can allow early detection of unsuspected.
Patient information leaflet
Pruebas genéticas
Pruebas genéticas is a type of medical test that identifies changes in chromosomes, genes or proteins. Genetic tests examine a person's DNA in a variety of ways to assess a person's genetic health. They are all designed to identify a particular gene that may cause a genetic disorder. Chromosomes are made from DNA (deoxyribonucleic acid). Genes are.
Patient information leaflet
Leucemia mieloide crónica
Chronic myeloid leukaemia (CML) is sometimes called chronic myelogenous leukaemia, chronic granulocytic leukaemia, or chronic myelocytic leukaemia. What is chronic myeloid leukaemia. You may be advised to have one or more of the following treatments: Imatinib tablets. This medicine is known as a tyrosine kinase inhibitor. The chemical tyrosine.
Patient information leaflet
Cáncer de boca
Mouth cancer can affect any part of the mouth, including the tongue and lips. The most common symptoms are having a sore or ulcer for more than three weeks. You should see your dentist or doctor if you have any symptoms in your mouth that are unusual. The outlook (prognosis) for people with mouth cancer is good if it is diagnosed early. What is.
Lecturas adicionales y referencias
- protein tyrosine phosphatase non-receptor type 22; MedlinePlus, National Library of Medicine.
- Arechiga AF, Habib T, He Y, Zhang X, Zhang ZY, Funk A, Buckner JH. Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol. 2009 Mar 15;182(6):3343-7. doi: 10.4049/jimmunol.0713370.
- LaBerge GS, Bennett DC, Fain PR, Spritz RA. PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not. J Invest Dermatol. 2008 Jul;128(7):1757-62. doi: 10.1038/sj.jid.5701233. Epub 2008 Jan 17.
- Laberge GS, Birlea SA, Fain PR, Spritz RA. The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population. Pigment Cell Melanoma Res. 2008 Apr;21(2):206-8. doi: 10.1111/j.1755-148X.2008.00443.x.
- Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK, Harley JB. The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis. Rheumatology (Oxford). 2007 Jan;46(1):49-56. doi: 10.1093/rheumatology/kel170. Epub 2006 Jun 7.
- Pradhan V, Borse V, Ghosh K. PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility. J Postgrad Med. 2010 Jul-Sep;56(3):239-42. doi: 10.4103/0022-3859.68651.
- Spritz RA. The genetics of generalized vitiligo and associated autoimmune diseases. Pigment Cell Res. 2007 Aug;20(4):271-8. doi: 10.1111/j.1600-0749.2007.00384.x.
- Vang T, Miletic AV, Bottini N, Mustelin T. Protein tyrosine phosphatase PTPN22 in human autoimmunity. Autoimmunity. 2007 Sep;40(6):453-61. doi: 10.1080/08916930701464897.
Únete a la conversación
Comparte tus pensamientos o experiencias con otros en nuestro comunidades de pacientes.
Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
Al suscribirte aceptas nuestros Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.