presenilin 2
Última actualización 19 Nov 2025
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El PSEN2 gene provides instructions for making a protein called presenilin 2. Presenilin 2 helps process proteins that transmit chemical signals from the cell membrane into the nucleus. Once in the nucleus, these signals turn on (activate) genes that are important for cell growth and maturation.
Normal function
El PSEN2 gene provides instructions for making a protein called presenilin 2. Presenilin 2 helps process proteins that transmit chemical signals from the cell membrane into the nucleus. Once in the nucleus, these signals turn on (activate) genes that are important for cell growth and maturation.
Presenilin 2 is best known for its role in processing amyloid precursor protein, which is found in the brain and other tissues. Research suggests that presenilin 2 works together with other enzymes to cut amyloid precursor protein into smaller segments (peptides). One of these peptides is called soluble amyloid precursor protein (sAPP), and another is called amyloid beta peptide. Recent evidence suggests that sAPP has growth-promoting properties and may play a role in the formation of neurons in the brain both before and after birth. Other functions of sAPP and amyloid beta peptide are under investigation.
Conditions referring to this gene or chromosome
Otros nombres
AD3-like protein
AD3L
AD3LP
AD4
AD5
Alzheimer's disease 3-like
E5-1
presenilin 2 (Alzheimer disease 4)
PS2 protein (alzheimer-associated)
PSN2_HUMAN
PSNL2
STM2
Related patient information and medicines
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Tratamiento para la diabetes tipo 2
Aunque diabetes cannot be cured, eso can be treated successfully. If a high blood sugar level is brought down to a normal level, your symptoms will ease an... One medicine (usually metformin) is used first but two or even three medicines may be needed. The rest of this leaflet is about medications to control blood glucose. According to.
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Diabetes
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Fiebre glandular
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Diabetes tipo 2
Diabetes tipo 2 puede occur at any age, including during childhood, but it occurs mainly in people aged over 40. The first-line treatment is diet, weight control and physical activity. Other treatments include reducing blood pressure if it is high, lowering high cholesterol levels, and also other me... This is called insulin resistance. You can.
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¿Puedo tomar suplementos de hierro y Sedoxil juntos?
Taking iron supplements at the same time as Sedoxil (mexazolam) may reduce how much of the medication your body absorbs. Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. ...ational purposes only and should not be relied upon as a substitute for.
Patient information leaflet
¿Puedo tomar Tetraciclina y Calcio juntos?
Calcium is a multivalent cation that undergoes 'chelation' with tetracycline. They bind together to form an insoluble complex in the digestive tract that is too large to pass through the gut wall. Using other medicines Taking multiple medicines. Our Medicines Interaction Checker helps tú check whether your prescriptions, over-the-counter.
Lecturas adicionales y referencias
- presenilin 2; MedlinePlus, National Library of Medicine.
- Bertram L, Tanzi RE. The current status of Alzheimer's disease genetics: what do we tell the patients? Pharmacol Res. 2004 Oct;50(4):385-96. doi: 10.1016/j.phrs.2003.11.018.
- Cordy JM, Hooper NM, Turner AJ. The involvement of lipid rafts in Alzheimer's disease. Mol Membr Biol. 2006 Jan-Feb;23(1):111-22. doi: 10.1080/09687860500496417.
- George-Hyslop PS, Rossor M. Alzheimer's disease. Unravelling the disease process. Lancet. 2001 Dec;358 Suppl:S1. doi: 10.1016/s0140-6736(01)07014-3. No abstract available.
- Harman D. Alzheimer's disease pathogenesis: role of aging. Ann N Y Acad Sci. 2006 May;1067:454-60. doi: 10.1196/annals.1354.065.
- Papassotiropoulos A, Fountoulakis M, Dunckley T, Stephan DA, Reiman EM. Genetics, transcriptomics, and proteomics of Alzheimer's disease. J Clin Psychiatry. 2006 Apr;67(4):652-70. doi: 10.4088/jcp.v67n0418.
- Rocchi A, Pellegrini S, Siciliano G, Murri L. Causative and susceptibility genes for Alzheimer's disease: a review. Brain Res Bull. 2003 Jun 30;61(1):1-24. doi: 10.1016/s0361-9230(03)00067-4.
- Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. doi: 10.1152/physrev.2001.81.2.741.
- St George-Hyslop PH. Genetic factors in the genesis of Alzheimer's disease. Ann N Y Acad Sci. 2000;924:1-7. doi: 10.1111/j.1749-6632.2000.tb05552.x.
- Thinakaran G, Parent AT. Identification of the role of presenilins beyond Alzheimer's disease. Pharmacol Res. 2004 Oct;50(4):411-8. doi: 10.1016/j.phrs.2003.12.026.
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