interleukin 7 receptor
Última actualización 18 Aug 2020
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El IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.
Normal function
El IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.
At the cell surface, the IL-7 receptor interacts with a protein called IL-7. IL-7 is a cytokine, which is a protein that regulates the activity of immune system cells. The receptor and cytokine fit together like a lock and its key, triggering a series of chemical signals inside the cell. In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells.
Similarly, the TSLP receptor interacts with the cytokine TSLP. Attachment of TSLP to its receptor triggers a set of signals that support proliferation and maturation of a variety of immune system cells.
Conditions referring to this gene or chromosome
Otros nombres
CD127
CD127 antigen
CDW127
IL-7 receptor subunit alpha
IL-7R subunit alpha
IL-7R-alpha
IL-7RA
IL7RA
IL7RA_HUMAN
ILRA
interleukin 7 receptor alpha chain
interleukin 7 receptor isoform H5-6
interleukin-7 receptor subunit alpha
interleukin-7 receptor subunit alpha precursor
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Lecturas adicionales y referencias
- interleukin 7 receptor; MedlinePlus, National Library of Medicine.
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- He R, Geha RS. Thymic stromal lymphopoietin. Ann N Y Acad Sci. 2010 Jan;1183:13-24. doi: 10.1111/j.1749-6632.2009.05128.x.
- Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallstrom E, Khademi M, Oturai A, Ryder LP, Saarela J, Harbo HF, Celius EG, Salter H, Olsson T, Hillert J. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet. 2007 Sep;39(9):1108-13. doi: 10.1038/ng2106. Epub 2007 Jul 29.
- Puel A, Ziegler SF, Buckley RH, Leonard WJ. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Nat Genet. 1998 Dec;20(4):394-7. doi: 10.1038/3877.
- Shochat C, Tal N, Bandapalli OR, Palmi C, Ganmore I, te Kronnie G, Cario G, Cazzaniga G, Kulozik AE, Stanulla M, Schrappe M, Biondi A, Basso G, Bercovich D, Muckenthaler MU, Izraeli S. Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med. 2011 May 9;208(5):901-8. doi: 10.1084/jem.20110580. Epub 2011 May 2.
- Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet. 2011 Sep 4;43(10):932-9. doi: 10.1038/ng.924.
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