Can I take Black cohosh and Solifenacin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking black cohosh and solifenacin together may increase the risk of side effects such as a dry mouth, blurred vision, constipation, or feeling overheated. There is also a small possibility that black cohosh could affect how your liver breaks down solifenacin, potentially leading to higher levels of the medicine in your body.
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Why this happens
Both substances can have 'anticholinergic' effects (blocking a specific chemical messenger in the body), which can lead to additive side effects. Additionally, some studies suggest black cohosh may interfere with liver enzymes (specifically CYP3A4) that are responsible for clearing solifenacin from your system.
What you should do
Use this combination with caution. If you decide to take both, monitor yourself closely for increased side effects like severe constipation, difficulty urinating, or extreme dry mouth. It is best to inform your doctor or pharmacist before starting black cohosh if you are already prescribed solifenacin for overactive bladder.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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